(S)-2,3-二氢-1,4-苯并二恶烷-2-甲胺合成路线 （共 15 条）
反应条件
hydrazine hydrate in 2-methoxy-ethanol Heating;
参考文献
Smith-Swintosky, Virginia L.; Reitz, Allen B.
Patent: US2007/155821 A1, 2007 ;
Location in patent: Page/Page column 16 ;
反应条件
hydrazine hydrate; Trimethylene glycol in methanol 2 h; Heating;
参考文献
Bolchi, Cristiano; Catalano, Paolo; Fumagalli, Laura; Gobbi, Marco; Pallavicini, Marco; Pedretti, Alessandro; Villa, Luigi; Vistoli, Giulio; Valoti, Ermanno
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4937 - 4951
反应条件
sodium hydroxide in dichloromethane
参考文献
Bolchi, Cristiano; Pallavicini, Marco; Fumagalli, Laura; Ruggeri, Paola; Valoti, Ermanno
Tetrahedron Asymmetry, 2013 , vol. 24, # 13-14 p. 796 - 800
反应条件
1: 78 percent / HCl / H2O / 5 h / 75 °C 2: 90 percent / TEA / CH2Cl2 / 2 h / 20 °C 3: 9.8 g / H2 / Pd/C / ethyl acetate; methanol / 3 h / 20 °C 4: 75 percent / K2CO3 / acetone / 5 h / Heating 5: 91 percent / NaN3 / dimethylformamide / 3 h / 90 °C 6: 88 percent / hydrazine hydrate / PdO / methanol / 2 h / Heating View Scheme
参考文献
Ferri; Pallavicini; Piccini; Valoti; Villa
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 12 SUPPL. p. 1153 - 1163
反应条件
1: 90 percent / TEA / CH2Cl2 / 2 h / 20 °C 2: 9.8 g / H2 / Pd/C / ethyl acetate; methanol / 3 h / 20 °C 3: 75 percent / K2CO3 / acetone / 5 h / Heating 4: 91 percent / NaN3 / dimethylformamide / 3 h / 90 °C 5: 88 percent / hydrazine hydrate / PdO / methanol / 2 h / Heating View Scheme
参考文献
Ferri; Pallavicini; Piccini; Valoti; Villa
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 12 SUPPL. p. 1153 - 1163
反应条件
chiral stationary phase including (R)-naphthylethyl-carbamate-functionalized CF6 in ethanol; n-heptane; trifluoroacetic acid T=20°C; Purification / work up;
参考文献
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; ARMSTRONG, Daniel, W.; PING, Sun; BREITBACH, Zachary, S.; WANG, Chunlei
Patent: WO2010/148191 A2, 2010 ;
Location in patent: Page/Page column 45-49; 64 ;
反应条件
1: 75 percent / K2CO3 / acetone / 5 h / Heating 2: 91 percent / NaN3 / dimethylformamide / 3 h / 90 °C 3: 88 percent / hydrazine hydrate / PdO / methanol / 2 h / Heating View Scheme
参考文献
Bolchi, Cristiano; Catalano, Paolo; Fumagalli, Laura; Gobbi, Marco; Pallavicini, Marco; Pedretti, Alessandro; Villa, Luigi; Vistoli, Giulio; Valoti, Ermanno
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4937 - 4951
反应条件
1: 9.8 g / H2 / Pd/C / ethyl acetate; methanol / 3 h / 20 °C 2: 75 percent / K2CO3 / acetone / 5 h / Heating 3: 91 percent / NaN3 / dimethylformamide / 3 h / 90 °C 4: 88 percent / hydrazine hydrate / PdO / methanol / 2 h / Heating View Scheme
参考文献
Bolchi, Cristiano; Catalano, Paolo; Fumagalli, Laura; Gobbi, Marco; Pallavicini, Marco; Pedretti, Alessandro; Villa, Luigi; Vistoli, Giulio; Valoti, Ermanno
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4937 - 4951
反应条件
1: 56 percent / KOH / ethanol / 24 h / Heating 2: 78 percent / HCl / H2O / 5 h / 75 °C 3: 90 percent / TEA / CH2Cl2 / 2 h / 20 °C 4: 9.8 g / H2 / Pd/C / ethyl acetate; methanol / 3 h / 20 °C 5: 75 percent / K2CO3 / acetone / 5 h / Heating 6: 91 percent / NaN3 / dimethylformamide / 3 h / 90 °C 7: 88 percent / hydrazine hydrate / PdO / methanol / 2 h / Heating View Scheme
参考文献
Bolchi, Cristiano; Catalano, Paolo; Fumagalli, Laura; Gobbi, Marco; Pallavicini, Marco; Pedretti, Alessandro; Villa, Luigi; Vistoli, Giulio; Valoti, Ermanno
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4937 - 4951
反应条件
1: 91 percent / NaN3 / dimethylformamide / 3 h / 90 °C 2: 88 percent / hydrazine hydrate / PdO / methanol / 2 h / Heating View Scheme
参考文献
Bolchi, Cristiano; Catalano, Paolo; Fumagalli, Laura; Gobbi, Marco; Pallavicini, Marco; Pedretti, Alessandro; Villa, Luigi; Vistoli, Giulio; Valoti, Ermanno
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4937 - 4951
