(S)-2,3-二氢-1,4-苯并二恶烷-2-甲胺合成路线 （共 15 条）
反应条件
1: H2 / Pd/C 2: K2CO3 / acetone / Heating 3: dimethylformamide / Heating 4: NH2-NH2*H2O / 2-methoxy-ethanol / Heating View Scheme
参考文献
Ferri; Pallavicini; Piccini; Valoti; Villa
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 12 SUPPL. p. 1153 - 1163
反应条件
1: (R)-glycidyl p-toluenesulfonate; benzene-1,2-diol With potassium carbonate in N,N-dimethyl-formamide T=60°C; 22 h; 2: p-toluenesulfonyl chloride in N,N-dimethyl-formamide T=0 - 20°C; 20 h; 3: potassium phtalimide Further stages;
参考文献
McComsey, David F.; Smith-Swintosky, Virginia L.; Parker, Michael H.; Brenneman, Douglas E.; Malatynska, Ewa; White, H. Steve; Klein, Brian D.; Wilcox, Karen S.; Milewski, Michael E.; Herb, Mark; Finley, Michael F. A.; Liu, Yi; Lubin, Mary Lou; Qin, Ning; Reitz, Allen B.; Maryanoff, Bruce E.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9019 - 9030
反应条件
1: dimethylformamide / Heating 2: NH2-NH2*H2O / 2-methoxy-ethanol / Heating View Scheme
参考文献
Ferri; Pallavicini; Piccini; Valoti; Villa
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 12 SUPPL. p. 1153 - 1163
反应条件
1: K2CO3 / acetone / Heating 2: dimethylformamide / Heating 3: NH2-NH2*H2O / 2-methoxy-ethanol / Heating View Scheme
参考文献
Ferri; Pallavicini; Piccini; Valoti; Villa
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 12 SUPPL. p. 1153 - 1163
反应条件
1: methanol / 0.17 h / 23 °C 2: Chiralcel OJ column / hexane; isopropyl alcohol / |Resolution of racemate 3: sodium hydroxide / dichloromethane View Scheme
参考文献
Bolchi, Cristiano; Pallavicini, Marco; Fumagalli, Laura; Ruggeri, Paola; Valoti, Ermanno
Tetrahedron Asymmetry, 2013 , vol. 24, # 13-14 p. 796 - 800
