3-丁炔-2-(R)-甲基吡咯烷合成路线 （共 11 条）
反应条件
copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride in acetonitrile T=20°C; Sonogashira reaction;
参考文献
Cowart, Marlon D.; Pu, Yu-Ming; Ku, Yi-Yin; Grieme, Timothy A.; Gupta, Ashok K.; Plata, Daniel J.; Faghih, Ramin; Gfesser, Gregory A.
Patent: US2004/54185 A1, 2004 ;
Location in patent: Page 10 ;
US 20040054185 A1
反应条件
1: (R)-2-methylpyrrolidine L-tartrate With potassium carbonate in acetonitrile
T=50°C; 24 h;
2: 3-butynyl p-tosylate in acetonitrile
T=23 - 50°C; 25 h;
参考文献
Cowart, Marlon; Faghih, Ramin; Curtis, Michael P.; Gfesser, Gregory A.; Bennani, Youssef L.; Black, Lawrence A.; Pan, Liping; Marsh, Kennan C.; Sullivan, James P.; Esbenshade, Timothy A.; Fox, Gerard B.; Hancock, Arthur A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 38 - 55
反应条件
potassium carbonate in acetonitrile
T=85°C; 16 h;
参考文献
Cowart, Marlon D.; Pu, Yu-Ming; Ku, Yi-Yin; Grieme, Timothy A.; Gupta, Ashok K.; Plata, Daniel J.; Faghih, Ramin; Gfesser, Gregory A.
Patent: US2004/54185 A1, 2004 ;
Location in patent: Page 10 ;
US 20040054185 A1
参考文献
Cowart, Marlon D.; Ku, Yi-Yin; Chang, Sou-Jen; Fernando, Dilinie P.; Grieme, Timothy A.; Altenbach, Robert J.
Patent: US2004/224953 A1, 2004 ;
反应条件
potassium carbonate in acetonitrile
参考文献
Sun, Minghua; Zhao, Chen; Gfesser, Gregory A.; Thiffault, Christine; Miller, Thomas R.; Marsh, Kennan; Wetter, Jill; Curtis, Michael; Faghih, Ramin; Esbenshade, Timothy A.; Hancock, Arthur A.; Cowart, Marlon
Journal of Medicinal Chemistry, 2005 , vol. 48, # 20 p. 6482 - 6490
反应条件
1: 96 percent / Et3N / CH2Cl2 / 12 h / 20 °C
2: 54 percent / LiEt3BH / tetrahydrofuran / Heating
3: 96 percent / HCl gas / ethyl acetate / 2 h / 20 °C
4: K2CO3 / acetonitrile / 6 h / Heating
View Scheme
参考文献
Ku, Yi-Yin; Pu, Yu-Ming; Grieme, Tim; Sharma, Padam; Bhatia, Ashok V.; Cowart, Marlon
Tetrahedron, 2006 , vol. 62, # 18 p. 4584 - 4589
反应条件
1: 54 percent / LiEt3BH / tetrahydrofuran / Heating
2: 96 percent / HCl gas / ethyl acetate / 2 h / 20 °C
3: K2CO3 / acetonitrile / 6 h / Heating
View Scheme
参考文献
Ku, Yi-Yin; Pu, Yu-Ming; Grieme, Tim; Sharma, Padam; Bhatia, Ashok V.; Cowart, Marlon
Tetrahedron, 2006 , vol. 62, # 18 p. 4584 - 4589
反应条件
potassium carbonate in acetonitrile
T=55°C; 48 h;
参考文献
Gfesser, Gregory A.; Faghih, Ramin; Bennani, Youssef L.; Curtis, Michael P.; Esbenshade, Timothy A.; Hancock, Arthur A.; Cowart, Marlon D.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2559 - 2563
反应条件
1: 86 percent / H2; Et3N / Pd/C / methanol / 20 °C
2: 96 percent / HCl gas / ethyl acetate / 2 h / 20 °C
3: K2CO3 / acetonitrile / 6 h / Heating
View Scheme
参考文献
Ku, Yi-Yin; Pu, Yu-Ming; Grieme, Tim; Sharma, Padam; Bhatia, Ashok V.; Cowart, Marlon
Tetrahedron, 2006 , vol. 62, # 18 p. 4584 - 4589
反应条件
1: 96 percent / HCl gas / ethyl acetate / 2 h / 20 °C
2: K2CO3 / acetonitrile / 6 h / Heating
View Scheme
参考文献
Ku, Yi-Yin; Pu, Yu-Ming; Grieme, Tim; Sharma, Padam; Bhatia, Ashok V.; Cowart, Marlon
Tetrahedron, 2006 , vol. 62, # 18 p. 4584 - 4589
