4-羟基-3-甲基-[1,1-联苯]-4-甲腈合成路线 （共 5 条）
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tripotassium phosphate monohydrate in water; isopropyl alcohol
T=70°C; Suzuki-Miyaura coupling; 3 h; Inert atmosphere;
参考文献
Jensen, Thomas Binderup; Terazzi, Emmanuel; Buchwalder, Kerry-Lee; Guenee, Laure; Nozary, Homayoun; Schenk, Kurt; Heinrich, Benoit; Donnio, Bertrand; Guillon, Daniel; Piguet, Claude
Inorganic Chemistry, 2010 , vol. 49, # 18 p. 8601 - 8619
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate in water; isopropyl alcohol
T=70°C; Suzuki-Miyaura Coupling; 15 h; Inert atmosphere;
参考文献
Dutronc, Thibault; Terazzi, Emmanuel; Guenee, Laure; Buchwalder, Kerry-Lee; Spoerri, Aurore; Emery, Daniel; Mareda, Jiri; Floquet, Sebastien; Piguet, Claude
Chemistry - A European Journal, 2013 , vol. 19, # 26 p. 8447 - 8456
反应条件
1: Pd(PPh3)4; aq. Na2CO3 / ethanol; benzene
2: BBr3 / CH2Cl2
View Scheme
参考文献
Gfesser, Gregory A.; Faghih, Ramin; Bennani, Youssef L.; Curtis, Michael P.; Esbenshade, Timothy A.; Hancock, Arthur A.; Cowart, Marlon D.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2559 - 2563
反应条件
1: bromine / dichloromethane / 0 - 20 °C
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / isopropyl alcohol; water / 15 h / 70 °C / |Inert atmosphere
View Scheme
参考文献
Dutronc, Thibault; Terazzi, Emmanuel; Guenee, Laure; Buchwalder, Kerry-Lee; Spoerri, Aurore; Emery, Daniel; Mareda, Jiri; Floquet, Sebastien; Piguet, Claude
Chemistry - A European Journal, 2013 , vol. 19, # 26 p. 8447 - 8456
反应条件
1: hydrogenchloride; water / 0.5 h
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / isopropyl alcohol; water / 15 h / 70 °C / |Inert atmosphere
View Scheme
参考文献
Dutronc, Thibault; Terazzi, Emmanuel; Guenee, Laure; Buchwalder, Kerry-Lee; Spoerri, Aurore; Emery, Daniel; Mareda, Jiri; Floquet, Sebastien; Piguet, Claude
Chemistry - A European Journal, 2013 , vol. 19, # 26 p. 8447 - 8456
