4,4,4-三氟-1-丁醇合成路线 （共 22 条）
反应条件
boric acid trimethyl ester; di-tert-butyl peroxide T=130°C; 18 h;
参考文献
Honeywell International Inc.
Patent: US2005/256331 A1, 2005 ;
Location in patent: Page/Page column 5 ;
参考文献
ICI Americas Inc.
Patent: US4552883 A1, 1985 ;
反应条件
1: tetrahydrofuran-2-one With potassium hydroxide in water T=50 - 140°C; P=150.015 - 760.051 Torr; 2: 1,1,1-trifluoro-4-iodobutane in water T=75 - 140°C; 7 h; Product distribution / selectivity;
参考文献
Tosoh F-Tech, Inc.
Patent: EP1403238 A1, 2004 ;
Location in patent: Page 4 ;
反应条件
potassium hydroxide; water in gamma-butyro-lactone T=90 - 100°C; 18.8 h; Product distribution / selectivity;
参考文献
Tosoh Corporation; Tosoh F-Tech Inc.
Patent: JP2005/187423 A, 2005 ;
Location in patent: Page/Page column 6 ;
反应条件
lithium aluminium tetrahydride in diethyl ether 3 h; Heating;
参考文献
Ratier, Max; Pereyre, Michel; Davies, Alwyn G.; Sutcliffe, Roger
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984 , p. 1907 - 1916
反应条件
sodium hydroxide in water T=90°C; 36 h; Product distribution / selectivity;
参考文献
Tosoh F-Tech, Inc.
Patent: EP1403238 A1, 2004 ;
Location in patent: Page 5 ;
反应条件
tetrahydrofuran-2-one in acetic acid T=75 - 140°C; 7 h; Product distribution / selectivity;
参考文献
Tosoh F-Tech, Inc.
Patent: EP1403238 A1, 2004 ;
Location in patent: Page 4 ;
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
McBee et al.
Journal of the American Chemical Society, 1950 , vol. 72, p. 5071
反应条件
(i) H2, PtO2, Et2O, (ii) LiAlH4; Multistep reaction;
参考文献
Pegolotti,J.A.; Young,W.G.
Journal of the American Chemical Society, 1961 , vol. 83, p. 3258 - 3262
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Gavlin; Maguire
Journal of Organic Chemistry, 1956 , vol. 21, p. 1342,1346
