4-氨基-2,6-二甲基嘧啶合成路线 （共 38 条）
反应条件
pyridine; dichloromethane anschliessendes Hydrolysieren;
参考文献
Nordmark-Werke
Patent: DE967224 , 1952 ;
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Nordmark-Werke
Patent: DE949469 , 1952 ;
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Nordmark-Werke
Patent: DE967884 , 1941 ;
DRP/DRBP Org.Chem.
反应条件
iodine; chlorine in acetic acid 1.) room temp., 30 min, 2.) 60 deg C, 3 h;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Yamanaka, Hiroshi
Synthesis, 1984 , # 3 p. 252 - 254
反应条件
sulfuric acid; water; dihydrogen peroxide; iodine 1.) CCl4, 3 h, 70 deg C, 2.) 1 h, reflux; Yield given. Multistep reaction;
参考文献
Zeuner, F.; Niclas, H.-J.
Journal fuer Praktische Chemie (Leipzig), 1989 , vol. 331, # 2 p. 324 - 330
反应条件
2: 2,6-dimethyl-pyrimidin-4-ylamine; pyridine View Scheme
参考文献
CIBA
Patent: US2429184 , 1943 ;
反应条件
sodium hydroxide in dimethyl sulfoxide 2 h; Ambient temperature;
参考文献
Zeuner, F.; Niclas, H.-J.; Reck, G.; Schenk, H.
Journal fuer Praktische Chemie (Leipzig), 1991 , vol. 333, # 4 p. 561 - 571
反应条件
selenium; triethylamine in toluene
T=150°C; 4 h;
参考文献
Ling, Gang; Chen, Jingzhu; Lu, Shiwei
Journal of Chemical Research - Part S, 2003 , # 7 p. 442 - 444
反应条件
1.) 100 deg C, 15 min; 2.) methanol, 1 h;
参考文献
Auzou; Desiles; Rips
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 345 - 348
反应条件
selenium; triethylamine in toluene
T=150°C; 4 h;
参考文献
Ling, Gang; Chen, Jingzhu; Lu, Shiwei
Journal of Chemical Research - Part S, 2003 , # 7 p. 442 - 444
反应条件
1.) 100 deg C, 15 min; 2.) methanol, 1 h;
参考文献
Auzou; Desiles; Rips
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 345 - 348
反应条件
selenium; triethylamine in toluene
T=150°C; 4 h;
参考文献
Ling, Gang; Chen, Jingzhu; Lu, Shiwei
Journal of Chemical Research - Part S, 2003 , # 7 p. 442 - 444
