(5-溴-2-氯苯基)(4-乙氧苯基)甲酮合成路线 （共 9 条）
反应条件
AlCl3, aluminium chloride in dichloromethane T=0°C; 1 h;
参考文献
WO2012/25857 A1, ;
Page/Page column 20 ;
WO 2012/025857 A1
反应条件
1: 5-bromo-2-chloro-benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 2: o-methylmethoxybenzene With AlCl3, aluminium chloride in dichloromethane T=20°C; 2 h; Cooling with ice;
参考文献
US2013/23486 A1, ;
Paragraph 0088 ;
反应条件
1: o-methylmethoxybenzene With AlCl3, aluminium chloride in dichloromethane T=-5 - 0°C; 2: 5-bromo-2-chlorobenzoyl chloride in dichloromethane T=0 - 5°C;
参考文献
US2004/138439 A1, ;
Page 18 ;
US 20040138439 A1
反应条件
AlCl3 in dichloromethane; N,N-dimethyl-formamide
参考文献
US2002/137903 A1, ;
US 20020137903 A1
US6515117 B2, ;
反应条件
1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 12 h / 20 °C 2: AlCl3, aluminium chloride / dichloromethane / 1 h / 0 °C View Scheme
参考文献
WO2012/25857 A1, ;
WO 2012/025857 A1
反应条件
1.1: potassium carbonate / acetone / 0.5 h / 20 °C 1.2: 3 h / Reflux 2.1: AlCl3, aluminium chloride / dichloromethane / 1 h / 0 °C View Scheme
参考文献
WO2012/25857 A1, ;
WO 2012/025857 A1
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran T=10 - 15°C; 0.5 h; Inert atmosphereIndustry scale; 2: With AlCl3, aluminium chloride in tetrahydrofuran T=-5 - 70°C; 20 h; Inert atmosphere; 3: With water T=0 - 40°C; Inert atmosphere;
参考文献
WO2010/22313 A2, ;
Page/Page column 35-37 ;
WO 2010/022313 A2
反应条件
potassium hydroxide; BF3.Et2O; Et3SiH in water; acetonitrile
参考文献
US2002/137903 A1, ;
US 20020137903 A1
US6515117 B2, ;
反应条件
1: AlCl3, aluminium chloride / dichloromethane / 12 h / 20 °C / Inert atmosphere
2: boron trifluoride diethyl etherate; triethylsilane / dichloromethane; diethyl ether; acetonitrile / 16 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Wang, Michael
Patent: US2014/51648 A1, 2014 ;
