(2-氨基苯基)-(4-叔丁基苯基)-甲酮合成路线 （共 6 条）
反应条件
hydrogen; palladium on activated charcoal in methanol
T=6°C; P=3750.3 Torr; 20 h;
参考文献
Dannhardt, Gerd; Fiebich, Bernd L; Schweppenhaeuser, Johannes
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 2 p. 147 - 161
反应条件
n-butyllithium in tetrahydrofuran; cyclohexane
T=-78°C; 0.5 h;
参考文献
Goodell, John R.; Puig-Basagoiti, Francesc; Forshey, Brett M.; Shi, Pei-Yong; Ferguson, David M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 6 p. 2127 - 2137
反应条件
1: 37 percent / AlCl3 / CH2Cl2 / 20 °C
2: 76 percent / hydrogen / 10 percent Pd-C / methanol / 20 h / 6 °C / 3750.3 Torr
View Scheme
参考文献
Dannhardt, Gerd; Fiebich, Bernd L; Schweppenhaeuser, Johannes
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 2 p. 147 - 161
反应条件
1: 37 percent / AlCl3 / CH2Cl2 / 20 °C
2: 76 percent / hydrogen / 10 percent Pd-C / methanol / 20 h / 6 °C / 3750.3 Torr
View Scheme
参考文献
Dannhardt, Gerd; Fiebich, Bernd L; Schweppenhaeuser, Johannes
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 2 p. 147 - 161
反应条件
1: 51.5 percent / triethylamine / aq. ethanol / 2 h / Heating
2: 53.8 percent / n-BuLi / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C
View Scheme
参考文献
Goodell, John R.; Puig-Basagoiti, Francesc; Forshey, Brett M.; Shi, Pei-Yong; Ferguson, David M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 6 p. 2127 - 2137
反应条件
(i) PCl5, (ii) AlCl3, (iii) H2SO4; Multistep reaction;
参考文献
Hall,J.H. et al.
Journal of the American Chemical Society, 1972 , vol. 94, p. 4952 - 4958
