3-(4-甲基苯甲酰)丙酸合成路线 （共 57 条）
反应条件
1: H2SO4
2: p-TsOH / Heating
View Scheme
参考文献
Taylor, Edward C.; Conley, Richard A.; Katz, Alan H; McKillop, Alexander
Journal of Organic Chemistry, 1984 , vol. 49, # 20 p. 3840 - 3841
反应条件
hydrogenchloride; aluminium trichloride in dichloromethane
参考文献
Rohm and Haas Company
Patent: US5552409 A1, 1996 ;
反应条件
hydrogenchloride; chlorine; aluminium trichloride in anhydrous dichloroethane; hexane; toluene
参考文献
Sankyo Company Limited
Patent: US4052395 A1, 1977 ;
参考文献
Taylor, Edward C.; Conley, Richard A.; Katz, Alan H; McKillop, Alexander
Journal of Organic Chemistry, 1984 , vol. 49, # 20 p. 3840 - 3841
反应条件
perchloric acid; bromine; acetic acid; sodium bromide in water
T=19.9 - 49.9°C; ΔH(excit.), ΔS(excit.); KineticsThermodynamic data;
参考文献
Knott
Journal of the Chemical Society, 1945 , p. 455,457
反应条件
1: triethylamine / tetrahydrofuran / 0.5 h / -20 °C
2: triethylamine / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Kozikowski, A. P.; Ma, D.; Brewer, James; Sun, S.; Costa, E.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2908 - 2920
反应条件
1: With hydrogenchloride; zinc in water
Inert atmosphereReflux;
2: With lithium aluminium tetrahydride in diethyl ether
T=20°C; Inert atmosphere;
参考文献
Kawakami; Kitani; Yuasa; Abe; Moriwaki; Kagoshima; Terasawa; Tahara
European Journal of Medicinal Chemistry, 1996 , vol. 31, # 9 p. 683 - 692
