1,2,3,4-四氢喹啉-2-羧酸乙酯合成路线 （共 5 条）
反应条件
1: With hydrogen; acetic acid; palladium on activated carbon T=20°C; P=3102.97 Torr; 2 h; glass reactor sealed; 2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
Abbott Laboratories
Patent: US2008/153871 A1, 2008 ;
Location in patent: Page/Page column 32 ;
反应条件
sulfuric acid; dihydrogen peroxide T=120°C; 0.583333 h;
参考文献
Gracheva, I. N.; Tochilkin, A. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1988 , vol. 24, p. 65 - 67
Khimiya Geterotsiklicheskikh Soedinenii, 1988 , vol. 24, # 1 p. 77 - 79
反应条件
1: 97 percent / Raney alloy/10percent NaOH / 1 h / 20 °C 2: 82 percent / H2O2/H2SO4 / 0.58 h / 120 °C View Scheme
参考文献
Gracheva, I. N.; Tochilkin, A. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1988 , vol. 24, p. 65 - 67
Khimiya Geterotsiklicheskikh Soedinenii, 1988 , vol. 24, # 1 p. 77 - 79
参考文献
Maj, Anna M.; Suisse, Isabelle; Meliet, Catherine; Hardouin, Christophe; Agbossou-Niedercorn, Francine
Tetrahedron Letters, 2012 , vol. 53, # 35 p. 4747 - 4750
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 25°C; 5 h; Heating / reflux;
2: With water; sodium sulfate in tetrahydrofuran
参考文献
Gruenenthal GmbH
Patent: US2008/306084 A1, 2008 ;
Location in patent: Page/Page column 56 ;
US 20080306084 A1
