2-(1-已炔)苯甲酸甲酯合成路线 （共 4 条）
反应条件
1: methyl 2-iodobenzoate With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; triphenylphosphine
T=20°C; 1 h; Inert atmosphere;
2: hex-1-yne T=0 - 20°C; Inert atmosphere;
参考文献
Li, Yao; Yang, Xiaoyu; Liu, Yunpeng; Zhu, Cunsheng; Yang, You; Yu, Biao
Chemistry - A European Journal, 2010 , vol. 16, # 6 p. 1871 - 1882
反应条件
1: 89 percent / H2SO4 / 2.5 h / Heating
2: 96 percent / Pd(PPh3)2Cl2; CuI; (i-Pr)2NEt / dimethylformamide / 18 h / 20 °C
View Scheme
参考文献
Gabriele, Bartolo; Salerno, Giuseppe; Fazio, Alessia; Pittelli, Rosina
Tetrahedron, 2003 , vol. 59, # 33 p. 6251 - 6259
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; diethylamine
Sonogashira coupling; 3 h; Heating;
参考文献
Knight, David W.; Lewis, Paul B.M.; Abdul Malik; Mshvidobadze, Elena V.; Vasilevsky, Sergei F.
Tetrahedron Letters, 2002 , vol. 43, # 50 p. 9187 - 9189
反应条件
PPh3 gold(I) chloro complex; silver trifluoromethanesulfonate in 1,4-dioxane
T=100°C; 6 h;
参考文献
Aikawa, Haruo; Tago, Sakie; Umetsu, Kazuteru; Haginiwa, Naomichi; Asao, Naoki
Tetrahedron, 2009 , vol. 65, # 9 p. 1774 - 1784
