(6-苯基-3-吡啶)甲醇合成路线 （共 9 条）
反应条件
manganese(IV) oxide in chloroform 3.5 h; Heating;
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
thionyl chloride in toluene T=20 - 100°C; 1 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1228067 B1, 2004 ;
Location in patent: Page 57 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C; 0.5 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1228067 B1, 2004 ;
Location in patent: Page 57 ;
反应条件
sodium tetrahydroborate in ethanol
T=20°C; 0.5 h;
参考文献
Zeng, Xianshun; Batsanov, Andrei S.; Bryce, Martin R.
Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9589 - 9594
反应条件
aq. NaOH in tetrahydrofuran; methanol; dichloromethane; water
参考文献
Merck and Co., Inc.
Patent: US5872136 A1, 1999 ;
反应条件
1: 94 percent / aq. Na2CO3 / tetrakis(triphenylphosphine)palladium / tetrahydrofuran; toluene / 48 h / 80 °C
2: 99 percent / sodium borohydride / ethanol / 0.5 h / 20 °C
View Scheme
参考文献
Zeng, Xianshun; Batsanov, Andrei S.; Bryce, Martin R.
Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9589 - 9594
反应条件
1: 94 percent / aq. Na2CO3 / tetrakis(triphenylphosphine)palladium / tetrahydrofuran; toluene / 48 h / 80 °C
2: 99 percent / sodium borohydride / ethanol / 0.5 h / 20 °C
View Scheme
参考文献
Zeng, Xianshun; Batsanov, Andrei S.; Bryce, Martin R.
Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9589 - 9594
反应条件
lithium aluminium tetrahydride in diethyl ether
Heating;
参考文献
Nishikawa; Shindo; Ishii; Nakamura; Kon; Uno
Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 583 - 593
反应条件
1: 91 percent / Na2CO3, Pd(PPh3)4 / 1,2-dimethoxy-ethane / 16 h / 80 °C
2: 89 percent / LiAlH4 / tetrahydrofuran / 4 h / Ambient temperature
View Scheme
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
