2-碘-4-(三氟甲基)苯酚合成路线 （共 3 条）
反应条件
iodine; sodium hydrogencarbonate; thiourea in tetrahydrofuran; water
参考文献
Mylari, Banavara L.
Patent: US2002/143017 A1, 2002 ;
US 20020143017 A1
反应条件
hydrogenchloride; chloramine-T; sodium iodide in ethyl acetate; N,N-dimethyl-formamide
参考文献
Millennium Pharmaceutical, Inc.
Patent: US2003/55084 A1, 2003 ;
反应条件
1.1: TMSOTf; TMEDA / diethyl ether / 0.5 h / 0 - 25 °C
1.2: TMEDA; n-BuLi / diethyl ether / 1 h / -78 °C
1.3: 62 percent / I2 / diethyl ether; tetrahydrofuran / 2 h / -78 °C
2.1: aq. NaOH / ethanol / 2 h
View Scheme
参考文献
Ganta, Ashok; Snowden, Timothy S.
Synlett, 2007 , # 14 p. 2227 - 2231
