3,4-二甲氧基苯甲酰乙腈合成路线 （共 6 条）
反应条件
in toluene; acetonitrile
参考文献
Takeda Chemical Industries
Patent: US5747486 A1, 1998 ;
反应条件
n-butyllithium in tetrahydrofuran; hexane; water; acetonitrile
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: US6180653 B2, 2001 ;
反应条件
1: acetonitrile With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: methyl 3,4-dimethoxybenzoate in tetrahydrofuran; hexane T=-78 - -45°C; Further stages.;
参考文献
Fang, Zhenglai; Song, Yunlong; Sarkar, Taradas; Hamel, Ernest; Fogler, William E.; Agoston, Gregory E.; Fanwick, Phillip E.; Cushman, Mark
Journal of Organic Chemistry, 2008 , vol. 73, # 11 p. 4241 - 4244
反应条件
sodium hydride in tetrahydrofuran T=20°C;
参考文献
Kim, Ikyon; Song, Jong Hwan; Park, Chang Min; Jeong, Joon Won; Kim, Hyung Rae; Ha, Jin Ryul; No, Zaesung; Hyun, Young-Lan; Cho, Young Sik; Sook Kang, Nam; Jeon, Dong Ju
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 922 - 926
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6214838 B1, 2001 ;
参考文献
Bargellini; Forli-Forti
Gazzetta Chimica Italiana, 1911 , vol. 41 I, p. 755
