2-氨基-3-(邻甲苯基)丙酸乙酯合成路线 （共 16 条）
反应条件
in various solvent(s) 6 h; Ambient temperatureCandida lypolythica esterase;
参考文献
Yee, Christopher; Blythe, Todd A.; McNabb, Thomas J.; Walts, Alan E.
Journal of Organic Chemistry, 1992 , vol. 57, # 13 p. 3525 - 3527
反应条件
phosphate buffer; Humicola amino esterase Ambient temperature; Title compound not separated from byproducts;
参考文献
Liu, Weiguo; Ray, Paul; Benezra, Steven A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 5 p. 553 - 560
反应条件
hydrogen; palladium on activated charcoal in methanol
T=20°C; 12 h;
参考文献
Harel, Tal; Rozen, Shlomo
Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6500 - 6503
反应条件
ammonium cerium(IV) nitrate in water
T=0°C; Oxidation; 0.5 h;
参考文献
Satoh, Tsuyoshi; Ozawa, Masaki; Takano, Koji; Chyouma, Tosio; Okawa, Akihiro
Tetrahedron, 2000 , vol. 56, # 26 p. 4415 - 4425
反应条件
1: F2; MeCN; H2O / CH2Cl2 / 0 °C
2: 78 percent / aq. tetrabutylammonium hydroxide / CH2Cl2 / 48 h / 20 °C
3: 90 percent / H2 / Pd/C / methanol / 12 h / 20 °C
View Scheme
参考文献
Harel, Tal; Rozen, Shlomo
Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6500 - 6503
反应条件
1: aq. tetrabutylammonium hydroxide / CH2Cl2 / 48 h / 20 °C
2: 90 percent / H2 / Pd/C / methanol / 12 h / 20 °C
View Scheme
参考文献
Harel, Tal; Rozen, Shlomo
Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6500 - 6503
反应条件
1: F2; MeCN; H2O / CH2Cl2 / 0 °C
2: aq. tetrabutylammonium hydroxide / CH2Cl2 / 48 h / 20 °C
3: 90 percent / H2 / Pd/C / methanol / 12 h / 20 °C
View Scheme
参考文献
Harel, Tal; Rozen, Shlomo
Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6500 - 6503
反应条件
1: 78 percent / aq. tetrabutylammonium hydroxide / CH2Cl2 / 48 h / 20 °C
2: 90 percent / H2 / Pd/C / methanol / 12 h / 20 °C
View Scheme
参考文献
Harel, Tal; Rozen, Shlomo
Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6500 - 6503
反应条件
1: 78 percent / aq. tetrabutylammonium hydroxide / CH2Cl2 / 48 h / 20 °C
2: 90 percent / H2 / Pd/C / methanol / 12 h / 20 °C
View Scheme
参考文献
Harel, Tal; Rozen, Shlomo
Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6500 - 6503
反应条件
1: ethyl (RS)-2-(benzylideneamino)propanoate With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-60°C; 1.33333 h; Inert atmosphere;
2: benzyl bromide in tetrahydrofuran; hexane
T=-60 - 15°C; 1.83333 h; Inert atmosphere; Product distribution / selectivity;
参考文献
BASF SE
Patent: US2011/144336 A1, 2011 ;
Location in patent: Page/Page column 7 ;
