1.1: 69 percent / LDA / tetrahydrofuran / 0.5 h / -78 °C 2.1: 94 percent / t-BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / 0.67 h / 70 °C 3.1: t-BuLi; MeMgBr / tetrahydrofuran; pentane / -80 °C 3.2: 81 percent / tetrahydrofuran; pentane / -80 °C 4.1: 67 percent / H2 / Pd(OH)2/C / methanol / 1 h / 20 °C 5.1: 76 percent / CAN / H2O / 0.5 h / 0 °C View Scheme

hydrogenchloride in ethanol

thionyl chloride

phosphate buffer; Humicola amino esterase Ambient temperature; Title compound not separated from byproducts;

in various solvent(s) 6 h; Ambient temperatureCandida lypolythica esterase;

phosphate buffer; Humicola amino esterase Ambient temperature; Title compound not separated from byproducts;