1H-吡咯并[2,3-B]吡啶-3-甲醛合成路线 （共 29 条）
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; propionic acid 1.) 21 deg C, 1 h, 2.) 100 deg C, 2 h;
参考文献
Sanchez-Obregon, Ruben; Fallis, Alex G.; Szabo, Arthur G.
Canadian Journal of Chemistry, 1992 , vol. 70, # 5 p. 1531 - 1536
反应条件
piperidine in pyridine Substitution; 24 h; Heating;
参考文献
Joseph, Benoit; Da Costa, Herve; Merour, Jean-Yves; Leonce, Stephane
Tetrahedron, 2000 , vol. 56, # 20 p. 3189 - 3196
反应条件
1: 72 percent / piperidine / pyridine / 3 h / 100 °C 2: 62 percent / nitrobenzene / 1 h / 140 °C View Scheme
参考文献
Minakata, Satoshi; Itoh, Shinobu; Komatsu, Mitsuo; Ohshiro, Yoshiki
Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 11 p. 2992 - 2997
反应条件
1: 1.) NaH / 1.) HMPA, 21 deg C, 2.) HMPA, 3 h 2: 60 percent / NaBH4 / aq. ethanol / 4 h / 21 °C 3: 45 percent / Ph3P, CCl4 / dimethylformamide / 108 h / 21 °C View Scheme
参考文献
ASCEPION PHARMACEUTICALS, INC.; JIANG, Shan; XING, Xinglong; WANG, Qishan; KONG, Ren
Patent: WO2011/23081 A1, 2011 ;
WO 2011/023081 A1
反应条件
1: 92 percent / NaH / tetrahydrofuran / 0 °C 2: 95 percent / NaClO2; NH2SO3H / dioxane; H2O / 0.5 h / 20 °C 3: 94 percent / HCl View Scheme
参考文献
Mouaddib, Abderrahim; Joseph, Benoit; Hasnaoui, Aissa; Merour, Jean-Yves
Tetrahedron Letters, 1999 , vol. 40, # 32 p. 5853 - 5854
反应条件
1: 92 percent / NaH / tetrahydrofuran / 0 °C 2: 95 percent / NaClO2; NH2SO3H / dioxane; H2O / 0.5 h / 20 °C 3: 91 percent / HCl View Scheme
参考文献
Mouaddib, Abderrahim; Joseph, Benoit; Hasnaoui, Aissa; Merour, Jean-Yves
Tetrahedron Letters, 1999 , vol. 40, # 32 p. 5853 - 5854
反应条件
1: 92 percent / NaH / tetrahydrofuran / 0 °C 2: 95 percent / NaClO2; NH2SO3H / dioxane; H2O / 0.5 h / 20 °C View Scheme
参考文献
Mouaddib, Abderrahim; Joseph, Benoit; Hasnaoui, Aissa; Merour, Jean-Yves
Tetrahedron Letters, 1999 , vol. 40, # 32 p. 5853 - 5854
反应条件
1: 77 percent / diethyl ether; 1,2-dimethoxy-ethane / 4 h / Heating 2: 20 percent / CrO3,Pyridine / CH2Cl2 / 0.5 h / Ambient temperature View Scheme
参考文献
Galvez, G.; Viladoms, P.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 665 - 667
反应条件
1: 95 percent / NaBH3CN; acetic acid / methanol / 18 h / 60 °C / pH 5 2: 65 percent / H2SO4 / methanol / 1 h / 60 °C View Scheme
参考文献
Oh, S. J.; Choe, Y. S.; Kim, S. E.; Choi, Y.; Lee, K. H.; et al.
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 40, p. 26 - 28
反应条件
sodium tetrahydroborate in ethanol T=20°C; 0.5 h;
参考文献
SU, Wei-Guo; JIA, Hong; DAI, Guangxiu
Patent: US2012/245178 A1, 2012 ;
Location in patent: Page/Page column 12 ;
US 20120245178 A1
