8-羟基-3,4-二氢-2(1H)-异喹啉羧酸叔丁酯合成路线 （共 3 条）
反应条件
1: BBr3 / CH2Cl2 / 3.5 h / -78 °C
2: NaOH / dioxane / 18 h
View Scheme
参考文献
Jesudason, Cynthia D.; Beavers, Lisa S.; Cramer, Jeffrey W.; Dill, Joelle; Finley, Don R.; Lindsley, Craig W.; Stevens, F. Craig; Gadski, Robert A.; Oldham, Samuel W.; Pickard, R. Todd; Siedem, Christopher S.; Sindelar, Dana K.; Singh, Ajay; Watson, Brian M.; Hipskind, Philip A.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3415 - 3418
反应条件
1: 70 percent / LAH / tetrahydrofuran / 5 h
2: BBr3 / CH2Cl2 / 3.5 h / -78 °C
3: NaOH / dioxane / 18 h
View Scheme
参考文献
Jesudason, Cynthia D.; Beavers, Lisa S.; Cramer, Jeffrey W.; Dill, Joelle; Finley, Don R.; Lindsley, Craig W.; Stevens, F. Craig; Gadski, Robert A.; Oldham, Samuel W.; Pickard, R. Todd; Siedem, Christopher S.; Sindelar, Dana K.; Singh, Ajay; Watson, Brian M.; Hipskind, Philip A.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3415 - 3418
反应条件
sodium hydroxide in 1,4-dioxane
18 h;
参考文献
Jesudason, Cynthia D.; Beavers, Lisa S.; Cramer, Jeffrey W.; Dill, Joelle; Finley, Don R.; Lindsley, Craig W.; Stevens, F. Craig; Gadski, Robert A.; Oldham, Samuel W.; Pickard, R. Todd; Siedem, Christopher S.; Sindelar, Dana K.; Singh, Ajay; Watson, Brian M.; Hipskind, Philip A.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3415 - 3418
