3-(2-噻吩甲酰基)丙酸合成路线 （共 45 条）
反应条件
1: With AlCl3, aluminium chloride in anhydrous dichloroethane T=20°C; 1 h; Heating / reflux; 2: With hydrogenchloride in anhydrous dichloroethane; water T=20°C; 0.166667 h;
参考文献
LUPIN LIMITED
Patent: WO2004/26848 A1, 2004 ;
Location in patent: Page 33 ;
反应条件
hydrogenchloride; sodium carbonate; aluminium trichloride in thiophene; water; nitrobenzene
参考文献
US4299769 A1, ;
US 4299769 A
反应条件
tin(IV) chloride in chlorobenzene T=2 - 15°C; Friedel Crafts acylation; 3.5 h;
参考文献
Smirnov; Afanas'Ev; Belen'kii
Chemistry of Heterocyclic Compounds, 2011 , vol. 46, # 10 p. 1199 - 1207
反应条件
sodium hydroxide in ethanol 1 h; Heating;
参考文献
Raposo, M. Manuela M.; Kirsch
Heterocycles, 2001 , vol. 55, # 8 p. 1487 - 1498
反应条件
dipyridinium dichromate in dichloromethane T=20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 24 p. 6185 - 6189
反应条件
tin(IV) chloride; benzene Behandeln des Reaktionsprodukts mit aethanol. Natronlauge.;
参考文献
Journal of the American Chemical Society, , vol. 69, p. 3018,3021
反应条件
1: TsOH / benzene / 16 h / Heating 2: aq. LiOH / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 16 p. 5107 - 5113
反应条件
AlCl3, aluminium chloride in dichloromethane T=40°C; 12 h;
参考文献
Smirnov; Afanas'Ev; Belen'kii
Chemistry of Heterocyclic Compounds, 2011 , vol. 46, # 10 p. 1199 - 1207
反应条件
1: trifluorormethanesulfonic acid / acetonitrile / 20 °C 2: dipyridinium dichromate / dichloromethane / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 24 p. 6185 - 6189
反应条件
AlCl3, aluminium chloride in dichloromethane T=20°C; 3 h;
参考文献
Chemistry of Heterocyclic Compounds, , vol. 46, # 10 p. 1199 - 1207
