3-(2-噻吩甲酰基)丙酸合成路线 （共 45 条）
反应条件
titanium tetrachloride in dichloromethane T=20°C; 3 h;
参考文献
Chemistry of Heterocyclic Compounds, , vol. 46, # 10 p. 1199 - 1207
参考文献
Journal of the Chemical Society, , p. 1196,1200
反应条件
tetrachlorosilane; nitrobenzene Behandeln des Reaktonsgemisches mit Aluminiumchlorid und anschliessend mit Thiophen;
参考文献
Doklady Akademii Nauk SSSR, , vol. 102, p. 113,115
Chem.Abstr., , p. 4899
反应条件
1: water 2: aqueous hydrochloric acid View Scheme
参考文献
Journal of the Chemical Society, , p. 1196,1200
反应条件
1.1: DCC; BtOH / CH2Cl2 / 0.5 h / 0 - 20 °C 1.2: 67 percent / CH2Cl2 / 20 °C 2.1: 64 percent / Lawesson's reagent / toluene / 0.42 h / Heating View Scheme
参考文献
Heterocycles, , vol. 55, # 8 p. 1487 - 1498
反应条件
1: 85 percent / 98percent N2H4, KOH / bis-(2-hydroxy-ethyl) ether / 7 h / 180 °C 2: 65 percent / H3PO4, Ac2O / 2.5 h / 120 °C 3: 88 percent / NH4OAc, NaBH3CN / methanol / 168 h / Ambient temperature View Scheme
参考文献
Cauquil-Caubere, Isoline; Kamenka, Jean-Marc
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 11 p. 867 - 877
反应条件
nickel; sodium carbonate
参考文献
Stetter,H.; Rajh,B.
Chemische Berichte, 1976 , vol. 109, p. 534 - 540
参考文献
Papa; Schwenk; Ginsberg
Journal of Organic Chemistry, 1949 , vol. 14, p. 723,729
参考文献
Badger; Sasse
Journal of the Chemical Society, 1957 , p. 3862,3867
Full Text Show Details
Badger et al.
Journal of the Chemical Society, 1959 , p. 440,442
反应条件
1: hydrazine hydrate; potassium hydroxide; diethylene glycol 2: thionyl chloride; pyridine; diethyl ether 3: aluminium chloride 4: hydrazine hydrate; potassium hydroxide; diethylene glycol / 215 °C 5: aluminium chloride 6: alkaline aqueous potassium hypobromite solution; dioxane View Scheme
参考文献
Cagniant; Cagniant
Bulletin de la Societe Chimique de France, 1953 , p. 62,68, 713, 717
