3-(2-噻吩甲酰基)丙酸合成路线 （共 45 条）
反应条件
Lawesson's reagent in toluene 8 h; Heating;
参考文献
Noe, Christian R.; Knollmueller, Max; Wagner, Ernst
Monatshefte fuer Chemie, 1986 , vol. 117, p. 621 - 630
反应条件
1: 1.) NH2NH2 2.) KOH / 1.) H2O 2.) heating 2: esterification 3: SnCl4 / benzene 4: BF3*Et2O / CHCl3 5: 70 percent / Raney nickel (W6) / ethanol / Heating 6: LAH / tetrahydrofuran View Scheme
参考文献
Bhalerao, U. T.; Rao, Jagadishwar S.; Tilak, B. D.
Tetrahedron Letters, 1984 , vol. 25, # 47 p. 5439 - 5440
反应条件
2: polyphosphoric acid; acetic anhydride View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 39, # 5 p. 334 - 338
反应条件
sodium hydroxide; nickel monoaluminide
参考文献
Journal of the Chemical Society, , p. 440,442
Journal of Organic Chemistry, , vol. 14, p. 723,729
参考文献
Journal of Organic Chemistry, , vol. 14, p. 723,729
参考文献
Journal of the Chemical Society, , p. 3862,3867
Journal of the Chemical Society, , p. 440,442
反应条件
2: polyphosphoric acid; acetic anhydride View Scheme
参考文献
Garcia-Dominguez; Ravina; Santana; Teran; Garcia-Mera; Orallo; Crespo; Fontenla
Archiv der Pharmazie, 1988 , vol. 321, # 10 p. 735 - 738
反应条件
1: 85 percent / 98percent N2H4, KOH / bis-(2-hydroxy-ethyl) ether / 7 h / 180 °C 2: 65 percent / H3PO4, Ac2O / 2.5 h / 120 °C 3: 95 percent / 98percent N2H4, KOH / bis-(2-hydroxy-ethyl) ether / 8 h / 180 °C 4: 72 percent / Ce(SO4)2 / aq. acetic acid / 1) -15 deg C, 2 h, 2) r.t., 2 h View Scheme
参考文献
Cauquil-Caubere, Isoline; Kamenka, Jean-Marc
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 11 p. 867 - 877
反应条件
potassium hydroxide; hydrazine hydrate in diethylene glycol T=180°C; 7 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 33, # 11 p. 867 - 877
反应条件
1: hydrazine hydrate; potassium hydroxide; diethylene glycol 2: thionyl chloride; pyridine; diethyl ether 3: aluminium chloride 4: hydroxylamine View Scheme
参考文献
Cagniant; Cagniant
Bulletin de la Societe Chimique de France, 1953 , p. 62,68, 713, 717
