3-(2-噻吩甲酰基)丙酸合成路线 （共 45 条）
参考文献
The Plessey Company plc
Patent: US4826977 A1, 1989 ;
反应条件
1: 1.) NH2NH2 2.) KOH / 1.) H2O 2.) heating
2: esterification
3: SnCl4 / benzene
4: BF3*Et2O / CHCl3
5: 70 percent / Raney nickel (W6) / ethanol / Heating
View Scheme
参考文献
Bhalerao, U. T.; Rao, Jagadishwar S.; Tilak, B. D.
Tetrahedron Letters, 1984 , vol. 25, # 47 p. 5439 - 5440
反应条件
sodium hydroxide; sodium tetrahydroborate in water
T=60°C; 6 h;
参考文献
Acheson, R. Morrin; Cooper, Martin W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1185 - 1193
反应条件
1: 72 percent / conc. HCl, Zn / 1.) room temperature, 50 h, 2.) reflux, 50 min
2: 100 percent / LiAlH4 / diethyl ether / 16 h / Heating
3: 7.1 g / pyridine / 48 h / 0 °C
View Scheme
参考文献
Acheson, R. Morrin; Cooper, Martin W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1185 - 1193
反应条件
1: 11.2 g / LiAlH4 / diethyl ether / 17 h / Heating
2: 8 g / MnO2 / CH2Cl2 / 24 h
View Scheme
参考文献
Acheson, R. Morrin; Cooper, Martin W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1185 - 1193
反应条件
1: 85 percent / N2H4*H2O / ethanol / 7 h / Heating
2: 83 percent / O2NC6H4SO3Na-m, NaOH / H2O; ethanol / 2 h / 100 °C
3: 68 percent / POCl3 / 1.5 h / 135 °C
4: 85 percent / N2H4*H2O / 3 h / Heating
View Scheme
参考文献
Steiner; Gries; Lenke
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 59 - 63
反应条件
1: 64 percent / 1,3-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / CH2Cl2 / 168 h
2: 32 percent / Lawesson's reagent / toluene / 0.25 h / Heating
View Scheme
参考文献
Raposo, M. Manuela M.; Sampaio, Ana M. B. A.; Kirsch
Synthesis, 2005 , # 2 art. no. T08004SS, p. 199 - 210
反应条件
hydrogenchloride; sodium hydroxide
1.) RT, 1 h, 2.) 24 h; Yield givenMultistep reaction;
参考文献
Ravina, Enrique; Negreira, Jesus; Cid, Jose; Masaguer, Christian F.; Rosa, Elizabeth; Rivas, M. Emilia; Fontenla, Jose A.; Loza, M. Isabel; Tristan, Helena; Cadavid, M. Isabel; Sanz, Ferran; Lozoya, Estrella; Carotti, Angelo; Carrieri, Antonio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2774 - 2797
反应条件
1: 1.) NH2NH2 2.) KOH / 1.) H2O 2.) heating
2: esterification
3: SnCl4 / benzene
View Scheme
参考文献
Bhalerao, U. T.; Rao, Jagadishwar S.; Tilak, B. D.
Tetrahedron Letters, 1984 , vol. 25, # 47 p. 5439 - 5440
反应条件
1: 85 percent / N2H4*H2O / ethanol / 7 h / Heating
2: 83 percent / O2NC6H4SO3Na-m, NaOH / H2O; ethanol / 2 h / 100 °C
View Scheme
参考文献
Steck; Brundage; Fletcher
Journal of Heterocyclic Chemistry, 1974 , vol. 11, # 5 p. 755 - 761
