3-(2-噻吩甲酰基)丙酸合成路线 （共 45 条）
反应条件
1: hydrazine hydrate; potassium hydroxide; diethylene glycol
2: thionyl chloride; pyridine; diethyl ether
3: aluminium chloride
4: hydrazine hydrate; potassium hydroxide; diethylene glycol / 215 °C
5: aluminium chloride
6: alkaline aqueous potassium hypobromite solution; dioxane
7: thionyl chloride / Behandeln des Reaktionsprodukts mit wss. Ammoniak
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参考文献
Cagniant; Cagniant
Bulletin de la Societe Chimique de France, 1953 , p. 62,68, 713, 717
反应条件
allyl bromide; 1,1'-carbonyldiimidazole
1.) CHCl3, 0.5 h, r.t.; 2.) CHCl3, r.t., 1 h; Yield given. Multistep reaction;
参考文献
Kamijo, Tetsuhide; Harada, Hiromu; Iizuka, Kinji
Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 5044 - 5047
反应条件
1: 4-(2'-thienyl)-4-oxobutanoic acid; chloroformic acid ethyl ester With triethylamine in N,N-dimethyl-formamide
T=-5°C; 0.25 h;
2: diisopropylamine in N,N-dimethyl-formamide
T=20°C;
参考文献
Raposo, M. Manuela M.; Kirsch
Heterocycles, 2001 , vol. 55, # 8 p. 1487 - 1498
参考文献
Knott
Journal of the Chemical Society, 1945 , p. 455,457
反应条件
hydrazine hydrate in ethanol
7 h; Heating;
参考文献
Steiner; Gries; Lenke
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 59 - 63
