ammonium cerium (IV) nitrate in water; acetonitrile T=0°C; Inert atmosphere; optical yield given as percent ee;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: nBuLi / tetrahydrofuran; hexane / 0.5 h / -30 &deg;C<br />1.2: 75 percent / TMDA / tetrahydrofuran; hexane / 2 h / -30 &deg;C<br />2.1: 100 percent / HCl / CH₂Cl₂; H₂O<br />3.1: 98 percent / TfOH / CH₂Cl₂ / 1 h / -78 &deg;C<br /> <br /> &nbsp;