5-溴-2-甲基-2H-吲唑合成路线 （共 9 条）
反应条件
1: 5-bromo-1H-indazole With sodium hydride in tetrahydrofuran T=0°C; 1 h; 2: methyl iodide in tetrahydrofuran T=0 - 20°C; 2 h;
参考文献
v. Auwers; Lange
Chemische Berichte, 1922 , vol. 55, p. 1141,1157
反应条件
1: in ethyl acetate T=20°C; Inert atmosphere; 2: With sodium hydroxide in water Cooling with ice;
参考文献
Britton, Thomas Charles; Dehlinger, Veronique; Fivush, Adam Michael; Hollinshead, Sean Patrick; Vokits, Benjamin Paul
Patent: US2009/253750 A1, 2009 ;
Location in patent: Page/Page column 6 ;
反应条件
1: 5-bromo-1H-indazole With sodium methylate in tetrahydrofuran 0.5 h; 2: methyl iodide in tetrahydrofuran T=20°C; 5 h;
参考文献
SCHERING CORPORATION
Patent: WO2007/84451 A1, 2007 ;
Location in patent: Page/Page column 167 ;
WO 2007/084451 A1
反应条件
1.1: potassium carbonate / ethylene glycol dimethyl ether / 5 h / 40 °C 2.1: hydrazine hydrate / Reflux 3.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C 3.2: 2 h / 0 - 20 °C View Scheme
参考文献
NOVARTIS AG; DAI, Miao; FU, Xingnian; HE, Feng; JIANG, Lei; LI, Yue; LIANG, Fang; LIU, Lei; MI, Yuan; XU, Yao-chang; XUN, Guoliang; YAN, Xiaoxia; YU, Zhengtian; ZHANG, Ji, Yue
Patent: WO2011/20861 A1, 2011 ;
反应条件
1: glacial acetic acid / Einleiten von nitrosen Gasen 2: benzene 3: sodium methylate solution View Scheme
参考文献
v. Auwers; Lange
Chemische Berichte, 1922 , vol. 55, p. 1141,1157
反应条件
1: benzene 2: sodium methylate solution View Scheme
参考文献
v. Auwers; Lange
Chemische Berichte, 1922 , vol. 55, p. 1141,1157
反应条件
1: glacial acetic acid / durch Bromierung 2: concentrated hydriodic acid; red phosphorus / 110 °C 3: sodium methylate solution View Scheme
参考文献
v. Auwers; Lange
Chemische Berichte, 1922 , vol. 55, p. 1141,1157
反应条件
1: concentrated hydriodic acid; red phosphorus / 110 °C 2: sodium methylate solution View Scheme
参考文献
v. Auwers; Lange
Chemische Berichte, 1922 , vol. 55, p. 1141,1157
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane T=100°C; 1.5 h; Inert atmosphere;
参考文献
US2009/253750 A1, ;
Page/Page column 6 ;
