5-溴-1-甲基-1H-吲唑合成路线 （共 15 条）
参考文献
v. Auwers; Lange
Chemische Berichte, 1922 , vol. 55, p. 1141,1157
反应条件
1: 5-bromo-1-methyl-1H-indazole With n-butyllithium; n-butyl-magnesium chloride in tetrahydrofuran; hexanes; toluene T=-30 - 10°C; 2 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexanes; toluene T=-10°C; 1 h; 3: With hydrogenchloride; sodium hydrogencarbonate more than 3 stages;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/759 A1, 2006 ;
Location in patent: Page/Page column 22-23 ;
WO 2006/000759 A1
反应条件
triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride T=100°C; 24 h; Product distribution / selectivity;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 38 ;
US 20120277224 A1
反应条件
1.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 24 h / 100 °C 2.1: sodium hydroxide / methanol / 2 h / 65 °C 2.2: pH 3 View Scheme
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
US 20120277224 A1
反应条件
bromine; acetic acid
参考文献
v. Auwers; Lange
Chemische Berichte, 1922 , vol. 55, p. 1141,1157
