反式-1,3-二苯基-2-丙烯-1-醇合成路线 （共 38 条）
反应条件
1.1: n-butyllithium / diethyl ether; hexane / -78 - 0 °C
1.2: 75 percent / diethyl ether; hexane / 2 h / 0 °C
2.1: 88 percent / hydrogen / PdCu/SiO2 / ethanol / 25 °C / 760.05 Torr
View Scheme
参考文献
Spee; Boersma; Meijer; Slagt; Van Koten; Geus
Journal of Organic Chemistry, 2001 , vol. 66, # 5 p. 1647 - 1656
反应条件
MnN(salen-3,5-tBu2); phenyl silane in acetonitrile-D3
T=80°C; 3 h; Sealed tube;
参考文献
Chidara, Vamshi K.; Du, Guodong
Organometallics, 2013 , vol. 32, # 18 p. 5034 - 5037
反应条件
triphenylphosphine-3,3',3''-trisulfonic acid trisodium salt; water; diethylamine; palladium diacetate; heptakis(2,6-di-O-methyl)-beta-cyclodextrin
T=20°C; Substitution; 20 h;
参考文献
Widehem, Rodrigue; Lacroix, Thibaut; Bricout, Herve; Monflier, Eric
Synlett, 2000 , # 5 p. 722 - 724
反应条件
1: 96 percent / NaBO3*4H2O / acetic acid / 12 h / 20 °C
2: 74 percent / MsCl / pyridine / 12 h / 20 °C
3: 70 percent / tert-butyl hydroperoxide; n-butyllithium / tetrahydrofuran; toluene; hexane / 2 h / -20 - -10 °C
4: 82 percent / LiOtBu / dimethylsulfoxide; tetrahydrofuran / 2 h / 25 °C
View Scheme
参考文献
Evans, Paul; Johnson, Paul; Taylor, Richard J. K.
European Journal of Organic Chemistry, 2006 , # 7 p. 1740 - 1754
反应条件
sodium tetrahydroborate; Nd(EBAB)Cl3 in methanol
1 h; Ambient temperatureother reagents: Ce(EBAB)Cl3, Sm(PBAB)Cl3, Yb(PBAB)Cl3,; Product distribution;
参考文献
Swamy, S. Jagannatha; Kumar, B. Kishore
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 5 p. 484 - 486
反应条件
1: 70 percent / tert-butyl hydroperoxide; n-butyllithium / tetrahydrofuran; toluene; hexane / 2 h / -20 - -10 °C
2: 82 percent / LiOtBu / dimethylsulfoxide; tetrahydrofuran / 2 h / 25 °C
View Scheme
参考文献
Evans, Paul; Johnson, Paul; Taylor, Richard J. K.
European Journal of Organic Chemistry, 2006 , # 7 p. 1740 - 1754
反应条件
lt;(P)-NMe2 = o-(diphenylphosphino)-N,N-dimethyl anilinegt;; H2Irlt;*gt;lt;(P)-NClt;*gt;H2Megt;lt;(P)-NMe2gt; in isopropyl alcohol
T=83°C; 1 h;
参考文献
Farnetti, Erica; Nardin, Giorgio; Graziani, Mauro
Journal of the Chemical Society, Chemical Communications, 1989 , # 17 p. 1264 - 1265
反应条件
sodium carbonate
0.5 h;
参考文献
Sychkova, L. D.; Kalinkina, O. L.; Shabarov, Yu. S.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, p. 1277 - 1281
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 7 p. 1435 - 1440
反应条件
1: 62 percent / K2CO3
2: 96 percent / NaBO3*4H2O / acetic acid
3: 81 percent / MsCl, pyridine
4: 15 percent / tBuOOLi / tetrahydrofuran / 24 h / -78 - 20 °C
View Scheme
参考文献
Evans, Paul; Taylor, Richard J. K.
Tetrahedron Letters, 1997 , vol. 38, # 17 p. 3055 - 3058
反应条件
1: With C29H53FeN3Si2
T=23°C; 12 h;
2: With sodium hydroxide; water
regioselective reaction;
参考文献
Tondreau, Aaron M.; Lobkovsky, Emil; Chirik, Paul J.
Organic Letters, 2008 , vol. 10, # 13 p. 2789 - 2792
