反式-1,3-二苯基-2-丙烯-1-醇合成路线 （共 38 条）
反应条件
potassium fluoride; C46H34I4O6 in 1,4-dioxane
T=20°C; 144 h; optical yield given as percent eeenantioselective reaction;
参考文献
Yan, Hailong; Jang, Hyeong Bin; Lee, Ji-Woong; Kim, Hong Ki; Lee, Soon Won; Yang, Jung Woon; Song, Choong Eui
Angewandte Chemie - International Edition, 2010 , vol. 49, # 47 p. 8915 - 8917
反应条件
1: 62 percent / K2CO3 / methanol
2: 96 percent / NaBO3*4H2O / acetic acid / 12 h / 20 °C
3: 74 percent / MsCl / pyridine / 12 h / 20 °C
4: 70 percent / tert-butyl hydroperoxide; n-butyllithium / tetrahydrofuran; toluene; hexane / 2 h / -20 - -10 °C
5: 82 percent / LiOtBu / dimethylsulfoxide; tetrahydrofuran / 2 h / 25 °C
View Scheme
参考文献
Evans, Paul; Johnson, Paul; Taylor, Richard J. K.
European Journal of Organic Chemistry, 2006 , # 7 p. 1740 - 1754
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C
1.2: 70 percent / tetrahydrofuran / 1.5 h / 20 °C
2.1: 70 percent / tert-butyl hydroperoxide; n-butyllithium / tetrahydrofuran; toluene; hexane / 2 h / -20 - -10 °C
3.1: 82 percent / LiOtBu / dimethylsulfoxide; tetrahydrofuran / 2 h / 25 °C
View Scheme
参考文献
Evans, Paul; Johnson, Paul; Taylor, Richard J. K.
European Journal of Organic Chemistry, 2006 , # 7 p. 1740 - 1754
参考文献
Nomura
Bulletin de la Societe Chimique de France, 1925 , vol. <4> 37, p. 1246
反应条件
1: 52 percent / N-bromosuccinimide, azodiisobutyronitrile / CCl4 / 2 h / 82 °C
2: 83 percent / aq. sodium carbonate / 0.5 h
View Scheme
参考文献
Sychkova, L. D.; Kalinkina, O. L.; Shabarov, Yu. S.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, p. 1277 - 1281
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 7 p. 1435 - 1440
反应条件
1: 1) Mg 2) potassium bisulfate / 1) Grignard reaction 2) benzene, boiling
2: 52 percent / N-bromosuccinimide, azodiisobutyronitrile / CCl4 / 2 h / 82 °C
3: 83 percent / aq. sodium carbonate / 0.5 h
View Scheme
参考文献
Sychkova, L. D.; Kalinkina, O. L.; Shabarov, Yu. S.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, p. 1277 - 1281
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 7 p. 1435 - 1440
参考文献
Meerwein; Schmidt
Justus Liebigs Annalen der Chemie, 1925 , vol. 444, p. 233
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane
参考文献
Ruzziconi, Renzo; Santi, Claudio; Spizzichino, Sara
Tetrahedron Asymmetry, 2007 , vol. 18, # 14 p. 1742 - 1749
