4-羟基-3,6-二甲基-2(1h)-吡啶酮合成路线 （共 4 条）
反应条件
1: phosphoryl chloride / 210 °C 2: Raney nickel; sodium methylate; methanol / Hydrogenation View Scheme
参考文献
Prelog; Szpilfogel
Helvetica Chimica Acta, 1942 , vol. 25, p. 1306,1312
反应条件
1: N,N-diethylaniline; trichlorophosphate / 2 h / 90 - 95 °C / |Inert atmosphere; |Large scale 2: copper(l) iodide; pyridine; potassium tert-butylate / 2 h / |Inert atmosphere; |Reflux; |Large scale View Scheme
参考文献
Ruggeri, Sally Gut; Vanderplas, Brian C.; Anderson, Bruce G.; Breitenbach, Ralph; Urban, Frank J.; Stewart III, A. Morgan; Young, Gregory R.
Organic Process Research and Development, 2008 , vol. 12, # 3 p. 411 - 413
反应条件
N,N-diethylaniline; trichlorophosphate
T=90 - 95°C; 2 h; Inert atmosphereLarge scale;
参考文献
Ruggeri, Sally Gut; Vanderplas, Brian C.; Anderson, Bruce G.; Breitenbach, Ralph; Urban, Frank J.; Stewart III, A. Morgan; Young, Gregory R.
Organic Process Research and Development, 2008 , vol. 12, # 3 p. 411 - 413
参考文献
Pfizer Products Inc.
Patent: EP951906 A1, 1999 ;
