N-Cbz-L-天冬氨酸 1-甲酯合成路线 （共 25 条）
反应条件
1: in ethyl acetate T=20°C; 5 h; 2: With N,N-dicyclohexylamine in di-isopropyl ether 3: With hydrogenchloride in water; ethyl acetate pH=2;
参考文献
DAEWOONG PHARMACEUTICAL CO., LTD.; CHOI, Soo Jin; LEE, Byung Goo; OH, Seong Soo; KIM, Yong Tae; EO, Jin Yong; KIM, Hung Sop
Patent: WO2012/148246 A2, 2012 ;
Location in patent: Page/Page column 13 ;
反应条件
tert.-butylnitrite in acetonitrile 1.5 h; Heating;
参考文献
Adams, David R.; Bailey, Patrick D.; Collier, Ian D.; Heffernan, John D.; Stokes, Stephen
Chemical Communications, 1996 , # 3 p. 349 - 350
反应条件
tert-butyl methyl ether; Alcalase-cross-linked-enzyme-aggregates T=50°C; 16 h; Molecular sieveEnzymatic reaction; regioselective reaction;
参考文献
Nuijens, Timo; Kruijtzer, John A.W.; Cusan, Claudia; Rijkers, Dirk T.S.; Liskamp, Rob M.J.; Quaedflieg, Peter J.L.M.
Tetrahedron Letters, 2009 , vol. 50, # 23 p. 2719 - 2721
反应条件
pyridine in dichloromethane T=0°C; 18 h; var.time, var. reag.:Et3N, or add of cat.: DMAP; Yields of byproduct given;
参考文献
Jouin, P.; Castro, B.; Zeggaf, C.; Pantaloni, A.; Senet, J.P; et al
Tetrahedron Letters, 1987 , vol. 28, # 15 p. 1665 - 1668
反应条件
pyridine in dichloromethane T=0°C; 24 h; Yields of byproduct given;
参考文献
Jouin, P.; Castro, B.; Zeggaf, C.; Pantaloni, A.; Senet, J.P; et al
Tetrahedron Letters, 1987 , vol. 28, # 15 p. 1665 - 1668
反应条件
in methanol T=-10 - 20°C; 5.5 h;
参考文献
Chandan, Nandkishkor; Moloney, Mark G.
Tetrahedron Letters, 2013 , vol. 54, # 15 p. 1987 - 1990
反应条件
trifluoroacetic acid in dichloromethane Ambient temperature;
参考文献
Misiti; Santaniello; Zappia
Synthetic Communications, 1992 , vol. 22, # 6 p. 883 - 891
反应条件
sodium periodate; ruthenium trichloride in tetrachloromethane; water; acetonitrile 60 h;
参考文献
Ranganathan, Subramania; Ranganathan, Darshan; Bhattacharyya, Dipti
Tetrahedron Letters, 1991 , vol. 32, # 40 p. 5615 - 5618
反应条件
pyridine in dichloromethane T=0°C; 24 h; Yield given. Title compound not separated from byproducts;
参考文献
Jouin, P.; Castro, B.; Zeggaf, C.; Pantaloni, A.; Senet, J.P; et al
Tetrahedron Letters, 1987 , vol. 28, # 15 p. 1665 - 1668
反应条件
ruthenium trichloride; sodium periodate in tetrachloromethane; acetonitrile 60 h;
参考文献
Ranganathan; Muraleedharan; Bhattacharyya; Kundu
Journal of the Indian Chemical Society, 1998 , vol. 75, # 10-12 p. 583 - 589
