(3,5-二甲氧基苯基)乙酸合成路线 （共 46 条）
反应条件
1: sulfuric acid / |Reflux
2: trichlorophosphate / 20 - 100 °C
3: dihydrogen peroxide; sodium dihydrogenphosphate; sodium chlorite / water; acetonitrile / 4 h / 0 - 20 °C
4: sodium hydroxide; water / methanol / 3 h / 20 °C
5: acetic anhydride / toluene / 2 h / |Reflux
View Scheme
参考文献
RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter Ronald
Patent: US2013/281397 A1, 2013 ;
反应条件
1: 93 percent / concd. H2SO4 / benzene / Heating
2: 1.) POCl3 / 1.) 45 min, 2.) 25 deg C, 17 h
3: 85 percent / toluene / 18 h / Heating
4: 98 percent / H2 / 5percent Pd/C / methanol / 2327.2 Torr
5: NaH / 1,2-dimethoxy-ethane / 0.5 h / Heating
6: 20percent aq. HCl / aq. ethanol / 18 h / Heating
View Scheme
参考文献
Cannon; Hamer; Ilhan; Bhatnagar; Long
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 190 - 195
反应条件
1: 93 percent / concd. H2SO4 / benzene / Heating
2: 1.) POCl3 / 1.) 45 min, 2.) 25 deg C, 17 h
3: 85 percent / toluene / 18 h / Heating
4: 98 percent / H2 / 5percent Pd/C / methanol / 2327.2 Torr
5: NaH / 1,2-dimethoxy-ethane / 0.5 h / Heating
6: 20percent aq. HCl / aq. ethanol / 18 h / Heating
7: p-toluenesulfonic acid / benzene / Heating
View Scheme
参考文献
Cannon; Hamer; Ilhan; Bhatnagar; Long
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 190 - 195
反应条件
1: 93 percent / concd. H2SO4 / benzene / Heating
2: 1.) POCl3 / 1.) 45 min, 2.) 25 deg C, 17 h
3: 85 percent / toluene / 18 h / Heating
4: 98 percent / H2 / 5percent Pd/C / methanol / 2327.2 Torr
5: NaH / 1,2-dimethoxy-ethane / 0.5 h / Heating
6: 20percent aq. HCl / aq. ethanol / 18 h / Heating
7: p-toluenesulfonic acid / benzene / Heating
8: 1.) 80 deg C, 3 h, 2.) 130 deg C, 30 min
View Scheme
参考文献
Cannon; Hamer; Ilhan; Bhatnagar; Long
Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 190 - 195
反应条件
1: With sodium acetate; acetic anhydride
2: in methanol
Acidic aq. solution;
参考文献
Xiao, Chun Fen; Tao, Li Yang; Sun, Hong Yi; Wei, Wen; Chen, Yu; Fu, Li Wu; Zou, Yong
Chinese Chemical Letters, 2010 , vol. 21, # 11 p. 1295 - 1298
反应条件
1: 100 percent / LiAlH4 / tetrahydrofuran / 2 h / 0 - 20 °C
2: PCC / CH2Cl2 / 3 h
View Scheme
参考文献
Jamie, Joanne F.; Rickards, Rodney W.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 24 p. 3613 - 3621
