4-甲酰基-3,5-二氟苯甲酸叔丁酯合成路线 （共 3 条）
反应条件
sodium tetrahydroborate in methanol T=0°C; 0.333333 h;
参考文献
EXELIXIS, INC.; BOLLU, Venkataiah; BOREN, Brant, Clayton; DALGARD, Jackline, Eve; FLATT, Brenton, T.; HAQ, Nadia; HUDSON, Sarah; MOHAN, Raju; MORRISSEY, Michael; PRATT, Benjamin; WANG, Tie-lin
Patent: WO2010/93845 A1, 2010 ;
Location in patent: Page/Page column 151-152 ;
WO 2010/093845 A1
反应条件
1: tert-butyl 3,5-difluorobenzoate With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-78°C; 3 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
参考文献
EXELIXIS, INC.; BOLLU, Venkataiah; BOREN, Brant, Clayton; DALGARD, Jackline, Eve; FLATT, Brenton, T.; HAQ, Nadia; HUDSON, Sarah; MOHAN, Raju; MORRISSEY, Michael; PRATT, Benjamin; WANG, Tie-lin
Patent: WO2010/93845 A1, 2010 ;
Location in patent: Page/Page column 151-152 ;
WO 2010/093845 A1
反应条件
1.1: magnesium sulfate; sulfuric acid / toluene / 20 °C
2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C
2.2: 0.5 h / -78 °C
View Scheme
参考文献
EXELIXIS, INC.; BOLLU, Venkataiah; BOREN, Brant, Clayton; DALGARD, Jackline; FLATT, Brenton, T.; HAQ, Nadia; HUDSON, Sarah; MOHAN, Raju; MORRISSEY, Michael; PRATT, Benjamin
Patent: WO2011/71565 A1, 2011 ;
WO 2011/071565 A1
