3,5-二氟-4-甲酰苯甲腈合成路线 （共 4 条）
反应条件
sulfuric acid in tetrahydrofuran T=20°C; 72 h;
参考文献
ASTRAZENECA AB
Patent: WO2003/101956 A1, 2003 ;
Location in patent: Page 131 ;
WO 03/101956 A1
反应条件
1: 3,5-Difluorobenzonitrile With lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-78°C; 0.75 h;
参考文献
Olsen, Jacob; Seiler, Paul; Wagner, Bjoern; Fischer, Holger; Tschopp, Thomas; Obst-Sander, Ulrike; Banner, David W.; Kansy, Manfred; Mueller, Klaus; Diederich, Francois
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 9 p. 1339 - 1352
反应条件
sodium chlorite; potassium dihydrogenphosphate; aminosulfonic acid in water; dimethyl sulfoxide T=20°C; 1 h;
参考文献
WO2012/160464 A1, ;
Page/Page column 69 ;
WO 2012/160464 A1
反应条件
sodium tetrahydroborate in methanol T=0°C; 1.08333 h;
参考文献
ASTRAZENECA AB
Patent: WO2003/101424 A1, 2003 ;
Location in patent: Page 27 ;
WO 03/101424 A1
