(S)-(-)-1,1-二苯基-1,2-丙二醇合成路线 （共 9 条）
反应条件
1: With lithium borohydride in tetrahydrofuran T=20°C; 2: With water in tetrahydrofuran T=20 - 40°C; 8 h; 3: With hydrogenchloride in water T=90°C; 1 h;
参考文献
DSM IP ASSETS B.V.
Patent: WO2004/94367 A2, 2004 ;
Location in patent: Page 14-15 ;
反应条件
in tetrahydrofuran T=0°C; 10 h;
参考文献
Mikami, Koichi; Terada, Masahiro; Nakai, Takeshi
Journal of the American Chemical Society, 1990 , vol. 112, # 10 p. 3949 - 3954
反应条件
1: (S)-(+)-lactic acid methyl ester; Merrifield resin coupled silyl chloride With 4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=20°C; 0.333333 h; 2: Bromure de phenyl magnesium in tetrahydrofuran T=0 - 20°C; 3: With tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C;
参考文献
Meloni, Marco M.; Brown; White, Peter D.; Armour, Duncan
Tetrahedron Letters, 2002 , vol. 43, # 34 p. 6023 - 6026
反应条件
1: bromobenzene With magnesium in diethyl ether Heating; 2: (S)-lactic acid ethyl ester in diethyl ether Grignard reaction; Heating;
参考文献
Mueller, Simona; Afraz, Marcel Cyrus; De Gelder, Rene; Ariaans, Gerry J. A.; Kaptein, Bernard; Broxterman, Quirinus B.; Bruggink, Alle
European Journal of Organic Chemistry, 2005 , # 6 p. 1082 - 1096
反应条件
in tetrahydrofuran T=-78°C; 0.0833333 h;
参考文献
Shionhara, Tomoichi; Suzuki, Keisuke
Synthesis, 2003 , # 1 p. 141 - 146
参考文献
Rebiere, F.; Kagan, H.B.
Tetrahedron Letters, 1989 , vol. 30, # 28 p. 3659 - 3662
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Hamon,D.P.G. et al.
Australian Journal of Chemistry, 1974 , vol. 27, p. 2199 - 2204
反应条件
1: (S)-(+)-lactic acid methyl ester With 4-(N,N-dimethlyamino)pyridine; polystyrene siloxane resin; triethylamine in dichloromethane 1 h; 2: Bromure de phenyl magnesium in tetrahydrofuran T=-5 - 20°C; Grignard reaction; 3: With tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 2 h;
参考文献
Meloni, Marco M.; White, Peter D.; Armour, Duncan; Brown, Richard C.D.
Tetrahedron, 2007 , vol. 63, # 2 p. 299 - 311
反应条件
thionyl chloride; triethylamine
参考文献
Kagan, Henry B.; Rebiere, Francois; Samuel, Odile
Phosphorus, Sulfur and Silicon and the Related Elements, 1991 , vol. 58, # 1-4 p. 89 - 110
