(2Z)-(2,3-二氢-6-甲氧基-1H-茚-1-亚基)-乙腈合成路线 （共 3 条）
反应条件
1: H2; NH3 / Raney-cobalt / ethanol / 40 °C / 3000.24 Torr 2: Et3N / tetrahydrofuran / 0 °C 3: H2 / Ru(OCOCH3)2[(S)-BINAP] / methanol / 70 °C / 68255.5 Torr View Scheme
参考文献
Fukatsu, Kohji; Uchikawa, Osamu; Kawada, Mitsuru; Yamano, Toru; Yamashita, Masayuki; Kato, Koki; Hirai, Keisuke; Hinuma, Shuji; Miyamoto, Masaomi; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4212 - 4221
反应条件
1: cyanomethyl-phosphonic acid diethyl ester With sodium hydride
2: 6-methoxy-1-oxo-indane
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1199304 A1, 2002 ;
Location in patent: Referential example 26 ;
EP 1199304 A1
反应条件
1: cyanomethyl-phosphonic acid diethyl ester With sodium hydride in tetrahydrofuran
T=20°C; 0.5 h;
2: 6-methoxy-1-oxo-indane in tetrahydrofuran
T=20°C; Horner-Emmons olefination; 1 h;
参考文献
Fukatsu, Kohji; Uchikawa, Osamu; Kawada, Mitsuru; Yamano, Toru; Yamashita, Masayuki; Kato, Koki; Hirai, Keisuke; Hinuma, Shuji; Miyamoto, Masaomi; Ohkawa, Shigenori
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4212 - 4221
