3,4-二甲氧基苯甲酰乙酸乙酯合成路线 （共 32 条）
反应条件
sodium hydride in toluene; mineral oil
参考文献
Chen, Yi-Fong; Lin, Yi-Chien; Huang, Po-Kai; Chan, Hsu-Chin; Kuo, Sheng-Chu; Lee, Kuo-Hsiung; Huang, Li-Jiau
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5064 - 5075
反应条件
1: 2,2-Dimethyl-[1,3]dioxane-4,6-dione With pyridine in dichloromethane T=-5 - 0°C; 0.5 h; 2: 3,4-dimethoxybenzoic acid chloride in dichloromethane T=-5 - 25°C; 1.5 h; 3: ethanol With hydrogenchloride; water more than 3 stages;
参考文献
Genecare Research Institute Co., Ltd
Patent: EP1900728 A1, 2008 ;
Location in patent: Page/Page column 164-165 ;
反应条件
sodium acetate in ethanol 7 h; Heating;
参考文献
Mangla, V. K.; Bhakuni, D. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 9 p. 748 - 749
反应条件
dichloro(cycloocta-1,5-diene)palladium(II); N,N-dicyclohexylmethylamine; triethylamine; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; magnesium chloride; [(t-Bu)3PH]BF4 in 1,4-dioxane T=80°C; 18 h; Inert atmosphereGlovebox;
参考文献
Korsager, Signe; Nielsen, Dennis U.; Taaning, Rolf H.; Skrydstrup, Troels
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9763 - 9766
Angew. Chem., 2013 , vol. 125, # 37 p. 9945 - 9948
反应条件
1.1: 99 percent / thionyl chloride; urea / toluene / 3 h / 100 °C 2.1: magnesium; ethanol / toluene; CCl4 / 1 h / Heating 2.2: 95 percent / toluene; CCl4 / 0.5 h / 20 °C 3.1: 90 percent / p-TsOH*H2O / H2O / 7 h / Heating View Scheme
参考文献
Zotova, S. A.; Gololobova, T. M.; Stolyarchuk, A. A.; Stepanyuk, G. I.; Bobruk, V. P.; et al.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 1 p. 26 - 30
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 1 p. 35 - 39
反应条件
sodium ethanolate T=0 - 5°C;
参考文献
Zhu, Youquan; Zou, Xiaomao; Hu, Fangzhong; Yao, Changsheng; Liu, Bin; Yang, Huazheng
Journal of Agricultural and Food Chemistry, 2005 , vol. 53, # 24 p. 9566 - 9570
反应条件
n-butyllithium; N-cyclohexyl-N-isopropylamine 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 15 min; Yield given. Multistep reaction;
参考文献
Hackeloeer, Kristina; Schnakenburg, Gregor; Waldvogel, Siegfried R.
European Journal of Organic Chemistry, 2011 , # 31 p. 6314 - 6319
反应条件
1: 3,4-dimethoxy-benzoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran 0.5 h; Heating; 2: malonic acid ethyl ester monopotassium salt With magnesium chloride in tetrahydrofuran T=20°C; Further stages.;
参考文献
Jae; Winn; Von Geldern; Sorensen; Chiou; Nguyen; Marsh; Opgenorth
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3978 - 3984
反应条件
toluene-4-sulfonic acid in water 7 h; Heating;
参考文献
Jung, Jae-Chul; Park, Oee-Sook
Synthetic Communications, 2007 , vol. 37, # 10 p. 1665 - 1673
反应条件
zeolite Hβ in 1,2-dichloro-ethane 8 h; Heating;
参考文献
Balaji; Chanda, Bhanu M.
Tetrahedron, 1998 , vol. 54, # 43 p. 13237 - 13252
