3-氯-N-甲基-2-吡啶胺合成路线 （共 4 条）
反应条件
1: in tetrahydrofuran
T=100°C; 6 h;
2: With sodium hydrogencarbonate in tetrahydrofuran; water
T=20°C;
参考文献
Astellas Pharma Inc.
Patent: EP1632477 A1, 2006 ;
Location in patent: Page/Page column 17 ;
反应条件
4 A molecular sieve; tetrabutyl ammonium fluoride in tetrahydrofuran
1 h;
参考文献
Blanchard, Stephanie; Rodriguez, Ivan; Kuehm-Caubere, Catherine; Renard, Pierre; Pfeiffer, Bruno; Guillaumet, Gerald; Caubere, Paul
Tetrahedron, 2002 , vol. 58, # 18 p. 3513 - 3524
反应条件
1: 79 percent / NaH / tetrahydrofuran / -40 - 20 °C
2: 80 percent / TBAF; 4 Angstroem molecular sieves / tetrahydrofuran / 1 h
View Scheme
参考文献
Blanchard, Stephanie; Rodriguez, Ivan; Kuehm-Caubere, Catherine; Renard, Pierre; Pfeiffer, Bruno; Guillaumet, Gerald; Caubere, Paul
Tetrahedron, 2002 , vol. 58, # 18 p. 3513 - 3524
反应条件
1: 100 percent / aq. HCl / Heating
2: 79 percent / NaH / tetrahydrofuran / -40 - 20 °C
3: 80 percent / TBAF; 4 Angstroem molecular sieves / tetrahydrofuran / 1 h
View Scheme
参考文献
Blanchard, Stephanie; Rodriguez, Ivan; Kuehm-Caubere, Catherine; Renard, Pierre; Pfeiffer, Bruno; Guillaumet, Gerald; Caubere, Paul
Tetrahedron, 2002 , vol. 58, # 18 p. 3513 - 3524
