1: ethanol / 14 h / |Reflux 2: pyridine / dichloromethane / 1.5 h / 0 - 20 °C 3: trichlorophosphate / acetonitrile / 1 h / |Reflux; |Inert atmosphere 4: [[(η6-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine)]Ru]; formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C 5: water; sodium hydroxide / ethanol / 3 h / 20 °C 6: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C 7: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C View Scheme

1: 70 percent / ethanol / 4.5 h / Ambient temperature 2: 1) PCl5; 2) NaBH4 / 1) CHCl3, room t., 20 min; 2) MeOH, 1.5 h View Scheme

1: ethanol / 14 h / |Reflux 2: pyridine / dichloromethane / 1.5 h / 0 - 20 °C 3: trichlorophosphate / acetonitrile / 1 h / |Reflux; |Inert atmosphere 4: [[(η6-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine)]Ru]; formic acid; triethylamine / N,N-dimethyl-formamide / 20 °C 5: water; sodium hydroxide / ethanol / 3 h / 20 °C 6: thionyl chloride / dichloromethane / 1.5 h / 0 - 20 °C 7: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C View Scheme

1: 89 percent / ethanol / 7 h / Heating 2: 1) PCl5, 2) NaBH4 / 1) CHCl3, room temperature, 1 h, 2) CH3OH 3: 76 percent / conc. HCl / ethanol / 2 h / Heating View Scheme

potassium carbonate in acetone 4 h; Reflux;

暂无反应条件数据

1: 1) n-BuLi / 1) ether, 0 deg C, 1 h; 2) 8 h 2: ethyl chloroformate, NaHCO3 / benzene / 0.25 h 3: dimethylformamide / 20 h 4: 1) KOH; 2) HCl / 1) methanol, water, reflux, 1.5 h; 2) water, 2 h View Scheme

1: 83.5 percent / NaOH / 0.5 h / 70 °C 2: 1.) hydrogen chloride, 2.) Raney nickel / 1.) ethanol, RT, 21 h, 2.) ethanol, reflux, 4 h 3: 1.) ozone, 2.) dimethyl sulfide / 1.) CH2Cl2, -70 deg C, 10 min, 2.) CH2Cl2, RT, 1 h 4: 0.1 N sodium methoxide / ethanol / 0.5 h / 0 °C 5: NaBH4 / ethanol / 0.5 h / Ambient temperature 6: 70.7 percent / potassium carbonate / dimethylformamide / 0.5 h / Ambient temperature View Scheme

1: 1.) hydrogen chloride, 2.) Raney nickel / 1.) ethanol, RT, 21 h, 2.) ethanol, reflux, 4 h 2: 1.) ozone, 2.) dimethyl sulfide / 1.) CH2Cl2, -70 deg C, 10 min, 2.) CH2Cl2, RT, 1 h 3: 0.1 N sodium methoxide / ethanol / 0.5 h / 0 °C 4: NaBH4 / ethanol / 0.5 h / Ambient temperature 5: 70.7 percent / potassium carbonate / dimethylformamide / 0.5 h / Ambient temperature View Scheme

1: 48 percent / 1.) benzeneboronic acid / benzene / 96 h / Heating 2: 90 percent View Scheme