2-溴-4,5-甲氧基苯乙酸合成路线 （共 15 条）
反应条件
hydrogenchloride; acetic acid T=85 - 90°C; 24 h;
参考文献
Nimgirawath, S.; Srikirin, Y.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 3 p. 272 - 273
反应条件
1.1: SOCl2
2.1: 71 percent / aq. Na2CO3 / diethyl ether / 2 h / 23 - 27 °C
3.1: POCl3 / acetonitrile / 2 h / 80 - 83 °C
3.2: 8 percent / NaBH4 / methanol / 2 h / -78 °C
View Scheme
参考文献
Hashimoto, Naomi; Miyatani, Kumiko; Ohkita, Keiko; Ohishi, Yoshitaka; Kunitomo, Jun-Ichi; Kawasaki, Ikuo; Yamashita, Masayuki; Ohta, Shunsaku
Heterocycles, 2002 , vol. 57, # 11 p. 2149 - 2161
反应条件
1: thionyl chloride / toluene / 1.) 30 deg C, 45 min, 2.) reflux, 3 h
2: AlCl3 / CH2Cl2 / 3 h / Heating
3: 10 percent / 4 h / 185 - 190 °C
View Scheme
参考文献
Dominguez, Esther; Lete, Esther; Villa, M. Jesus; Iriondo, Carmen
Heterocycles, 1984 , vol. 22, # 5 p. 1217 - 1224
反应条件
1: thionyl chloride / toluene / 1.) 30 deg C, 45 min, 2.) reflux, 3 h
2: 1.) SnCl4, 2.) 6M HCl / 1.) CH2Cl2, RT, 2 h, 2.) RT, 16 h
View Scheme
参考文献
Dominguez, Esther; Lete, Esther; Villa, M. Jesus; Iriondo, Carmen
Heterocycles, 1984 , vol. 22, # 5 p. 1217 - 1224
反应条件
1: SOCl2 / 1 h / Heating
2: 6.38 g / aq. Na2CO3 / diethyl ether / 6 h / 20 °C
3: 76 percent / POCl3 / acetonitrile / 4 h / Heating
View Scheme
参考文献
Stenlake; Waigh; Dewar; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 515 - 524
