(E)-3,7-二甲基-2,6-辛二烯酸合成路线 （共 23 条）
反应条件
Candida antarctica lipase in tert-butyl alcohol T=60°C; 144 h; Enzymatic reaction;
参考文献
DR. ANDRE RIEKS - LABOR FUeR ENZYMTECHNOLOGIE GMBH
Patent: WO2005/12210 A2, 2005 ;
Location in patent: Page/Page column 44 ;
反应条件
1: triethylamine; pivaloyl chloride / tetrahydrofuran / -25 - -20 °C 2: lithium chloride 3: diethyl ether / -50 °C 4: hexamethyldisilazane / tetrahydrofuran / -78 °C 5: methyl-magnesium iodide / 0.17 h / 160 °C View Scheme
参考文献
Esumi, Tomoyuki; Yamamoto, Chihiro; Fukuyama, Yoshiyasu
Synlett, 2013 , vol. 24, # 14 art. no. ST-2013-U0439-L, p. 1845 - 1847
参考文献
Beereboom,J.J.
Journal of Organic Chemistry, 1965 , vol. 30, p. 4230 - 4234
Full Text View citing articles Show Details
Balant et al.
Helvetica Chimica Acta, 1951 , vol. 34, p. 722,726
反应条件
1: triethylamine; pivaloyl chloride / tetrahydrofuran / -25 - -20 °C 2: lithium chloride 3: diethyl ether / -50 °C 4: hexamethyldisilazane / tetrahydrofuran / -78 °C 5: methyl-magnesium iodide / 0.17 h / 160 °C View Scheme
参考文献
Esumi, Tomoyuki; Yamamoto, Chihiro; Fukuyama, Yoshiyasu
Synlett, 2013 , vol. 24, # 14 art. no. ST-2013-U0439-L, p. 1845 - 1847
反应条件
1: (i) NaOH, (ii) SOCl2, (iii) /BRN= 1098229/, Et3N
2: LiAlH4 / diethyl ether
View Scheme
参考文献
Bedoukian; Wolinsky
The Journal of organic chemistry, 1975 , vol. 40, # 15 p. 2154 - 2156
反应条件
lithium triethylborohydride; lt;(chlorosulfinyloxy)methylenegt;dimethylammonium chloride; triethylamine; lithium iodide
1.) THF, MeCN, -30 deg C, 1 h, 2.) THF, MeCN, -78 deg C, 15 min; Yield given. Multistep reaction;
参考文献
Khan; Prasada Rao
Journal of Chemical Research - Part S, 1998 , # 7 p. 402 - 403
反应条件
1: 82 percent / phosphate acid / toluene / 2 h / 100 °C
2: 91 percent / K2CO3 / acetone / 5 h / 20 °C
3: 85 percent / LiAlH4 / diethyl ether / 4 h / 20 °C
View Scheme
参考文献
Xiong, Yi; Wang, Kuiwu; Pan, Yuanjiang; Sun, Hongxiang; Tu, Jue
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 4 p. 786 - 789
反应条件
sulfuric acid in nitromethane
T=-40°C; 1 h;
参考文献
Lyashchuk, S. N.; Skrypnik, Yu. G.; Bezrodnyi, B. P.
Russian Journal of Organic Chemistry, 1993 , vol. 29, # 1.2 p. 109 - 114
Zhurnal Organicheskoi Khimii, 1993 , vol. 29, # 1 p. 130 - 136
反应条件
(i) NaOH, (ii) SOCl2, (iii) /BRN= 1098229/, Et3N; Multistep reaction;
参考文献
Bedoukian; Wolinsky
The Journal of organic chemistry, 1975 , vol. 40, # 15 p. 2154 - 2156
反应条件
phosphoric acid in toluene
T=100°C; Cyclization; 2 h;
参考文献
Gan, Yonghong; Li, Anpai; Pan, Xinfu; Chan, Albert S. C.; Yang, Teng-Kuei
Tetrahedron Asymmetry, 2000 , vol. 11, # 3 p. 781 - 787
Title/Abstract Full Text View citing articles Show Details
Yonghong, Gan; Xinfu, Pan
Journal of Chemical Research - Part S, 2000 , # 3 p. 130 - 132
