T=4°C; 0.25 h; hydrolysis ni brain P2-fraction (rats);

1: 3-hydroxy-1,3-dihydro-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one With sodium hydride in tetrahydrofuran T=20°C; deprotonation; 0.5 h; 2: succinic acid anhydride in tetrahydrofuran T=40°C; Addition; esterification; 2 h;