2-羟甲基-1,3-丙二醇合成路线 （共 16 条）
反应条件
toluene-4-sulfonic acid in tetrahydrofuran T=20°C; 2.5 h;
参考文献
Xu, Bin; Stephens, Andrew; Kirschenheuter, Gary; Greslin, Arthur F.; Cheng, Xiaoquin; Sennelo, Joe; Cattaneo, Marco; Zighetti, Maddalena L.; Chen, Aishe; Kim, Soon-Ai; Kim, Hak Sung; Bischofberger, Norbert; Cook, Gary; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 26 p. 5694 - 5709
反应条件
1: With perchloric acid in water T=20°C; 21 h; 2: With ammonium hydroxide in water pH=9;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP2065379 A1, 2009 ;
Location in patent: Page/Page column 18-19 ;
参考文献
Latour, Stephan; Wuest, James D.
Synthesis, 1987 , # 8 p. 742 - 744
反应条件
camphor-10-sulfonic acid in dichloromethane
T=20°C; 2 h;
参考文献
Ko, Haye Min; Lee, Dong Gil; Kim, Min Ah; Kim, Hak Joong; Park, Jaejoon; Lah, Myoung Soo; Lee, Eun
Tetrahedron, 2007 , vol. 63, # 26 p. 5797 - 5805
反应条件
toluene-4-sulfonic acid; lithium bromide in dichloromethane
168 h;
参考文献
Eisai Co., Ltd.
Patent: US2007/10542 A1, 2007 ;
Location in patent: Page/Page column 76 ;
反应条件
phosphorus tribromide
参考文献
Stetter; Boeckmann
Chemische Berichte, 1951 , vol. 84, p. 834,836
Full Text Show Details
Doering; Levy
Journal of the American Chemical Society, 1955 , vol. 77, p. 509,512
Full Text Show Details
Fedorow; Ssaweljewa
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1950 , p. 223,230
Chem.Abstr., 1951 , # 1501
