3,5-二氟-N-甲基苯胺合成路线 （共 7 条）
反应条件
1: formic acid With acetic anhydride
T=60°C; 3 h;
2: 3,5-difluoro-aniline in tetrahydrofuran
T=-20°C; 1.7 h;
3: With dimethylsulfide borane complex in tetrahydrofuran
T=70°C; 2.2 h; Further stages.;
参考文献
Herzon, Seth B.; Hartwig, John F.
Journal of the American Chemical Society, 2007 , vol. 129, # 21 p. 6690 - 6691
反应条件
sodium tetrahydroborate in tetrahydrofuran
T=20°C; 12 h;
参考文献
Zhang, Shu Lan; Zhai, Xin; Zhang, Shi Jiao; Yu, Hong Hao; Gong, Ping
Chinese Chemical Letters, 2010 , vol. 21, # 8 p. 939 - 942
反应条件
1: 82 percent / 2 h / Heating
2: LiAlH4 / diethyl ether / 3.5 h / Heating
View Scheme
参考文献
Florvall, Lennart; Fagervall, Ingrid; Larsson, Lars-Gunnar; Ross, Svante B.
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 2 p. 137 - 151
反应条件
lithium aluminium tetrahydride in diethyl ether
3.5 h; Heating;
参考文献
Florvall, Lennart; Fagervall, Ingrid; Larsson, Lars-Gunnar; Ross, Svante B.
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 2 p. 137 - 151
反应条件
1: SOCl2, DMF / CH2Cl2 / 4 h / Heating
2: conc. NH4OH / tetrahydrofuran / 0 °C
3: 1) Br2, aq. NaOH / 1) reflux, 2 h, 2) reflux, 2 h
4: LiAlH4 / diethyl ether / 3.5 h / Heating
View Scheme
参考文献
Florvall, Lennart; Fagervall, Ingrid; Larsson, Lars-Gunnar; Ross, Svante B.
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 2 p. 137 - 151
反应条件
1: 1) Br2, aq. NaOH / 1) reflux, 2 h, 2) reflux, 2 h
2: LiAlH4 / diethyl ether / 3.5 h / Heating
View Scheme
参考文献
Florvall, Lennart; Fagervall, Ingrid; Larsson, Lars-Gunnar; Ross, Svante B.
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 2 p. 137 - 151
反应条件
1: conc. NH4OH / tetrahydrofuran / 0 °C
2: 1) Br2, aq. NaOH / 1) reflux, 2 h, 2) reflux, 2 h
3: LiAlH4 / diethyl ether / 3.5 h / Heating
View Scheme
参考文献
Florvall, Lennart; Fagervall, Ingrid; Larsson, Lars-Gunnar; Ross, Svante B.
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 2 p. 137 - 151
