(2S,4S)-N-叔丁氧基羰基-4-三氟甲基脯氨酸合成路线 （共 13 条）
反应条件
1: tetrabutylammonium fluoride / tetrahydrofuran / 0 - 20 °C
2: 2.97 g / aqueous NH4Cl; tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
3: 78 percent / thionyl chloride; pyridine / 0.33 h / Heating
4: 90 percent / hydrogen / 10percent Pd/C / ethanol / 20 °C
View Scheme
参考文献
Qiu, Xiao-long; Qing, Feng-ling
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 7162 - 7164
反应条件
1: aqueous NaOH / tetrahydrofuran; H2O / 20 °C
2: 6.17 g / Et3N / tetrahydrofuran / 0 - 20 °C
3: 84 percent / chromium trioxide; pyridine / CH2Cl2 / 4 h / 20 °C
4: tetrabutylammonium fluoride / tetrahydrofuran / 0 - 20 °C
5: 2.97 g / aqueous NH4Cl; tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
6: 78 percent / thionyl chloride; pyridine / 0.33 h / Heating
7: 90 percent / hydrogen / 10percent Pd/C / ethanol / 20 °C
View Scheme
参考文献
Qiu, Xiao-long; Qing, Feng-ling
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 7162 - 7164
反应条件
1: 78 percent / thionyl chloride; pyridine / 0.33 h / Heating
2: 90 percent / hydrogen / 10percent Pd/C / ethanol / 20 °C
View Scheme
参考文献
Qiu, Xiao-long; Qing, Feng-ling
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 7162 - 7164
