4-溴-2,3,5,6-四氟苯甲酸合成路线 （共 6 条）
反应条件
1: 1,4-dibromo-2,3,5,6-tetrafluorobenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Inert atmosphere; 2: carbon dioxide T=-78 - 0°C;
参考文献
Aakeroey, Christer B.; Chopade, Prashant D.; Ganser, Claudia; Desper, John
Chemical Communications, 2011 , vol. 47, # 16 p. 4688 - 4690
反应条件
tert.-butylnitrite; nitrogen in acetonitrile
参考文献
THE WELLCOME FOUNDATION LIMITED; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Patent: EP279698 A3, 1990 ;
参考文献
Allergan Sales, Inc.
Patent: US6342602 B1, 2002 ;
Location in patent: Page column 26 ;
反应条件
phosphorus pentachloride Yield given;
参考文献
Reuman, Michael; Daum, Sol J.; Singh, Baldev; Wentland, Mark P.; Perni, Robert B.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 14 p. 2531 - 2540
反应条件
1: PCl5
2: 86 percent / BuLi
3: tetrahydrofuran / Ambient temperature
4: tetrahydrofuran / 1 h
5: 62 percent / K2CO3 / dimethylformamide / 1.5 h / 150 °C
6: 43 percent / HMPA, PdCl2(PPh3)2 / tetrahydrofuran / 24 h / Heating
7: 76 percent / NaH / tetrahydrofuran
8: 62 percent / Raney nickel / ethanol / 0.25 h / Heating
9: 75 percent / 1 M aq. HCl / 2 h / Heating
View Scheme
参考文献
Reuman, Michael; Daum, Sol J.; Singh, Baldev; Wentland, Mark P.; Perni, Robert B.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 14 p. 2531 - 2540
反应条件
in methanol; diethyl ether
参考文献
MERCK SERONO S.A.; THUNUGUNTLA, Siva Sanjeeva Rao; SUBRAMANYA, Hosahalli; KUNNAM, Satish Reddy; SANIVARU VIJAY, Sekhar Reddy; BINGI, Chakrapani; KUSANUR, Raviraj; SCHWARZ, Matthias; ARLT, Michael
Patent: WO2010/115736 A2, 2010 ;
Location in patent: Page/Page column 87 ;
WO 2010/115736 A2
