N-[[1-(3,5-二甲氧基l苯基)-1-甲基乙氧基]羰基]-甘氨酸合成路线 （共 8 条）
反应条件
sodium hydroxide in 1,4-dioxane
参考文献
Koenig,W.; Kernebeck,K.
Liebigs Annalen der Chemie, 1979 , p. 227 - 247
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 2105670/
2: (i) Py, CH2Cl2, (ii) N2H4*H2O, DMF
3: NaNO2, AcOH / dioxane
4: (i) <PhCH2NMe3>OH, MeOH, (ii) /BRN= 2471550/, Py
View Scheme
参考文献
Birr,C. et al.
Justus Liebigs Annalen der Chemie, 1972 , vol. 763, p. 162 - 172
反应条件
1: (i) Py, CH2Cl2, (ii) N2H4*H2O, DMF
2: NaNO2, AcOH / dioxane
3: (i) <PhCH2NMe3>OH, MeOH, (ii) /BRN= 2471550/, Py
View Scheme
参考文献
Birr,C. et al.
Justus Liebigs Annalen der Chemie, 1972 , vol. 763, p. 162 - 172
反应条件
1: NaNO2, AcOH / dioxane
2: (i) <PhCH2NMe3>OH, MeOH, (ii) /BRN= 2471550/, Py
View Scheme
参考文献
Birr,C. et al.
Justus Liebigs Annalen der Chemie, 1972 , vol. 763, p. 162 - 172
反应条件
1: (i) SOCl2, (ii) /BRN= 511834/
2: (i) Mg, Et2O, (ii) /BRN= 2105670/
3: (i) Py, CH2Cl2, (ii) N2H4*H2O, DMF
4: NaNO2, AcOH / dioxane
5: (i) <PhCH2NMe3>OH, MeOH, (ii) /BRN= 2471550/, Py
View Scheme
参考文献
Birr,C. et al.
Justus Liebigs Annalen der Chemie, 1972 , vol. 763, p. 162 - 172
反应条件
1: Et3N / dimethylformamide
2: aq. NaOH / dioxane
View Scheme
参考文献
Koenig,W.; Kernebeck,K.
Liebigs Annalen der Chemie, 1979 , p. 227 - 247
反应条件
(i) <PhCH2NMe3>OH, MeOH, (ii) /BRN= 2471550/, Py; Multistep reaction;
参考文献
Birr,C. et al.
Justus Liebigs Annalen der Chemie, 1972 , vol. 763, p. 162 - 172
反应条件
1: Ddz-L-Gly-OH With 4-methyl-morpholine; isobutyl chloroformate in dichloromethane
T=-20°C; 1 h; Inert atmosphere;
2: 2-(2-bromo-3,5-dinitrophenyl)ethanamine hydrochloride With triethylamine in dichloromethane; N,N-dimethyl-formamide
T=20°C; Inert atmosphere;
参考文献
Debieux, Jean-Luc; Bochet, Christian G.
Journal of Organic Chemistry, 2009 , vol. 74, # 12 p. 4519 - 4524
