hydrogen; triethylamine; (2,2',6,6'-CH3O-4,4'-Ph2P-3,3'-bipyridine)(p-cymene)RuCl2 in ethanol; dichloromethane T=50°C; P=4654.46 Torr; 22 h;

in dichloromethane; water

dihydrogen peroxide; acetic acid T=50°C;

1.1: 100 percent / sodium hydroxide / ethanol / cooling 2.1: 96 percent / sodium tungstate dihydrate; sulfuric acid; hydrogen peroxide / aliquat 336 / H2O; toluene / 45 °C 3.1: 92 percent / acetic anhydride / dimethylformamide / 24.5 h / 60 °C 4.1: xylene / 16 h / 130 °C 5.1: 110 g / aq. HCl / xylene; tetrahydrofuran / 2 h / 50 °C 6.1: potassium tert-butoxide / tetrahydrofuran / 1 h / -5 °C 6.2: 97 percent / tetrahydrofuran / 20 h / 22 °C 7.1: 94 percent / L-selectride / tetrahydrofuran / 1.5 h / -60 °C 8.1: 96 percent / diisobutylaluminium hydride / toluene / 1 h / -40 °C 9.1: potassium tert-butoxide / tetrahydrofuran / cooling 9.2: tetrahydrofuran; toluene / -20 - 20 °C 10.1: 5.6 kg / aq. HCl / tetrahydrofuran; toluene; dimethylformamide / 2 h / 45 °C 11.1: 74 percent / sulfamic acid; sodium chlorite / CH2Cl2; H2O / 0.5 h View Scheme

sodium chlorite; aminosulfonic acid in dichloromethane; water 0.5 h;

1.1: 96 percent / sodium tungstate dihydrate; sulfuric acid; hydrogen peroxide / aliquat 336 / H2O; toluene / 45 °C 2.1: 92 percent / acetic anhydride / dimethylformamide / 24.5 h / 60 °C 3.1: xylene / 16 h / 130 °C 4.1: 110 g / aq. HCl / xylene; tetrahydrofuran / 2 h / 50 °C 5.1: potassium tert-butoxide / tetrahydrofuran / 1 h / -5 °C 5.2: 97 percent / tetrahydrofuran / 20 h / 22 °C 6.1: 94 percent / L-selectride / tetrahydrofuran / 1.5 h / -60 °C 7.1: 96 percent / diisobutylaluminium hydride / toluene / 1 h / -40 °C 8.1: potassium tert-butoxide / tetrahydrofuran / cooling 8.2: tetrahydrofuran; toluene / -20 - 20 °C 9.1: 5.6 kg / aq. HCl / tetrahydrofuran; toluene; dimethylformamide / 2 h / 45 °C 10.1: 74 percent / sulfamic acid; sodium chlorite / CH2Cl2; H2O / 0.5 h View Scheme

1.1: 92 percent / acetic anhydride / dimethylformamide / 24.5 h / 60 °C 2.1: xylene / 16 h / 130 °C 3.1: 110 g / aq. HCl / xylene; tetrahydrofuran / 2 h / 50 °C 4.1: potassium tert-butoxide / tetrahydrofuran / 1 h / -5 °C 4.2: 97 percent / tetrahydrofuran / 20 h / 22 °C 5.1: 94 percent / L-selectride / tetrahydrofuran / 1.5 h / -60 °C 6.1: 96 percent / diisobutylaluminium hydride / toluene / 1 h / -40 °C 7.1: potassium tert-butoxide / tetrahydrofuran / cooling 7.2: tetrahydrofuran; toluene / -20 - 20 °C 8.1: 5.6 kg / aq. HCl / tetrahydrofuran; toluene; dimethylformamide / 2 h / 45 °C 9.1: 74 percent / sulfamic acid; sodium chlorite / CH2Cl2; H2O / 0.5 h View Scheme

1.1: 100 percent / sodium hydroxide / ethanol / cooling 2.1: 96 percent / sodium tungstate dihydrate; sulfuric acid; hydrogen peroxide / aliquat 336 / H2O; toluene / 45 °C 3.1: 92 percent / acetic anhydride / dimethylformamide / 24.5 h / 60 °C 4.1: xylene / 16 h / 130 °C 5.1: 110 g / aq. HCl / xylene; tetrahydrofuran / 2 h / 50 °C 6.1: potassium tert-butoxide / tetrahydrofuran / 1 h / -5 °C 6.2: 97 percent / tetrahydrofuran / 20 h / 22 °C 7.1: 94 percent / L-selectride / tetrahydrofuran / 1.5 h / -60 °C 8.1: 96 percent / diisobutylaluminium hydride / toluene / 1 h / -40 °C 9.1: potassium tert-butoxide / tetrahydrofuran / cooling 9.2: tetrahydrofuran; toluene / -20 - 20 °C 10.1: 5.6 kg / aq. HCl / tetrahydrofuran; toluene; dimethylformamide / 2 h / 45 °C 11.1: 74 percent / sulfamic acid; sodium chlorite / CH2Cl2; H2O / 0.5 h View Scheme

1.1: potassium tert-butoxide / tetrahydrofuran / 1 h / -5 °C 1.2: 97 percent / tetrahydrofuran / 20 h / 22 °C 2.1: 94 percent / L-selectride / tetrahydrofuran / 1.5 h / -60 °C 3.1: 96 percent / diisobutylaluminium hydride / toluene / 1 h / -40 °C 4.1: potassium tert-butoxide / tetrahydrofuran / cooling 4.2: tetrahydrofuran; toluene / -20 - 20 °C 5.1: 5.6 kg / aq. HCl / tetrahydrofuran; toluene; dimethylformamide / 2 h / 45 °C 6.1: 74 percent / sulfamic acid; sodium chlorite / CH2Cl2; H2O / 0.5 h View Scheme

1.1: xylene / 16 h / 130 °C 2.1: 110 g / aq. HCl / xylene; tetrahydrofuran / 2 h / 50 °C 3.1: potassium tert-butoxide / tetrahydrofuran / 1 h / -5 °C 3.2: 97 percent / tetrahydrofuran / 20 h / 22 °C 4.1: 94 percent / L-selectride / tetrahydrofuran / 1.5 h / -60 °C 5.1: 96 percent / diisobutylaluminium hydride / toluene / 1 h / -40 °C 6.1: potassium tert-butoxide / tetrahydrofuran / cooling 6.2: tetrahydrofuran; toluene / -20 - 20 °C 7.1: 5.6 kg / aq. HCl / tetrahydrofuran; toluene; dimethylformamide / 2 h / 45 °C 8.1: 74 percent / sulfamic acid; sodium chlorite / CH2Cl2; H2O / 0.5 h View Scheme