2,6,6-三甲基环己烯-1-甲醇合成路线 （共 39 条）
反应条件
1: With sodium tetrahydroborate in methanol T=0°C; Inert atmosphere; 2: With water in methanol
参考文献
BIKAM PHARMACEUTICALS, INC.; GARVEY, David, S.; LAROSA, Gregory, J.; GREENWOOD, Jeremy, Robert; BREWER, Mark, L.; QUACH, Tan; COTE, Jamie, B.; BERMAN, Judd
Patent: WO2010/147653 A1, 2010 ;
Location in patent: Page/Page column 155-156 ;
反应条件
1: With ozone in methanol T=-78°C; ozonization; 2: With sodium tetrahydroborate in methanol T=-78 - 20°C; Reduction;
参考文献
Abad, Antonio; Agullo, Consuelo; Arno, Manuel; Cunat, Ana C.; Garcia, M. Teresa; Zaragoza, Ramon J.
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 5916 - 5919
反应条件
carbon monoxide; C12H10FeO4; potassium carbonate in water; dimethyl sulfoxide T=100°C; P=7500.75 Torr; 20 h; Inert atmosphere; Overall yield = 88 percentChromat.;
参考文献
Tlili, Anis; Schranck, Johannes; Neumann, Helfried; Beller, Matthias
Chemistry - A European Journal, 2012 , vol. 18, # 50 p. 15935 - 15939
反应条件
vinyl acetate; yeast lipase from Candida cylindracea in diethyl ether T=20 - 24°C; 22 h; Yield given;
参考文献
Gamalevich; Serebryakov
Russian Chemical Bulletin, 1997 , vol. 46, # 1 p. 171 - 183
反应条件
1: aq. H2SO4 2: NaBH4 View Scheme
参考文献
Bhar, Shanta S.; Ramana
Journal of Organic Chemistry, 2004 , vol. 69, # 25 p. 8935 - 8937
参考文献
Kuhn; Hoffer
Chemische Berichte, 1934 , vol. 67, p. 357,359
参考文献
Kuhn; Hoffer
Chemische Berichte, 1934 , vol. 67, p. 357,359
反应条件
1.1: phosphorus tribromide / diethyl ether / 1 h / 0 - 20 °C 2.1: NaH; n-Buli / tetrahydrofuran / 1 h / 0 - 20 °C 3.1: SnCl4 / CH2Cl2 / 20.5 h / -10 - 20 °C 4.1: p-TsOH / benzene / 2 h / Heating 4.2: LiAlH4 / diethyl ether / 12 h / 20 °C 5.1: 90 percent / p-TsOH / acetone; H2O / 12 h / 20 °C 6.1: pyridine 7.1: dimethylsulfoxide 8.1: DIBAL / toluene / 2 h / 20 °C View Scheme
参考文献
Furuichi, Noriyuki; Hata, Toshiyuki; Soetjipto, Hartati; Kato, Mariko; Katsumura, Shigeo
Tetrahedron, 2001 , vol. 57, # 40 p. 8425 - 8442
反应条件
aluminum isopropoxide T=70 - 100°C; P=12 Torr; anschliessend Erhitzen mit 4-Methoxy-benzaldehyd unter 14 Torr auf 140-160grad;
参考文献
Lauchenauer; Schinz
Helvetica Chimica Acta, 1949 , vol. 32, p. 1273
反应条件
1.1: 64 percent / Hg(OAc)2 / 24 h / 170 °C 2.1: Mg; iodine 2.2: 81 percent / tetrahydrofuran / 8 h 3.1: 82 percent / pyridinium chlorochromate; NaOAc; molecular sieves 4 Angstroem / CH2Cl2 / 0.75 h / 20 °C View Scheme
参考文献
Srikrishna; Praveen Kumar
Tetrahedron Letters, 1997 , vol. 38, # 11 p. 2005 - 2006
