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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
隐黄质
合成路线
(共 17 条)
1638-05-7
(2E,4E,6E,8E,10E,12E)-2,7,11-三甲基-13-(2,6,6-三甲基-1-环己烯-1-基)-2,4,6,8,10,12-十三六烯醛
+
130696-70-7
→
反应条件
472-70-8
隐黄质
反应条件
(+/-)-2-Ethyloxirane in ethanol RefluxInert atmosphere;
参考文献
University of Maryland, College Park
Patent: US8222458 B2, 2012 ;
Location in patent: Page/Page column 28 ;
92760-20-8
+
54422-80-9
+
92760-19-5
→
反应条件
144-68-3
玉米黄质
+
472-70-8
隐黄质
+
24480-38-4
Alpha-隐黄素
反应条件
hydrogen; Pt/Al2O3 in ethyl acetate T=-15 - 40°C; P=760.051 - 2068.65 Torr; 2 - 26 h; Product distribution / selectivity;
参考文献
UNIVERSITY OF MARYLAND, COLLEGE PARK
Patent: WO2005/44769 A1, 2005 ;
Location in patent: Page/Page column 20-23; 29-30 ;
92760-20-8
+
54422-80-9
+
92760-19-5
→
反应条件
472-70-8
隐黄质
+
24480-38-4
Alpha-隐黄素
反应条件
hydrogen; 5 alumina-supported platinum catalyst in ethyl acetate T=40°C; P=760.051 Torr; 21 h; Sealed tubeInert atmosphere; Product distribution / selectivity;
参考文献
University of Maryland, College Park
Patent: US2010/280286 A1, 2010 ;
Location in patent: Page/Page column title page; 3; 7; 11-12 ;
127-40-2
叶黄素
→
反应条件
144-68-3
玉米黄质
+
472-70-8
隐黄质
+
24480-38-4
Alpha-隐黄素
反应条件
triethylsilane; trifluoroacetic acid in 1,2-dichloro-ethane T=20°C; 8 h; Product distribution / selectivity;
参考文献
Khachik, Frederick
Patent: US2003/220525 A1, 2003 ;
Location in patent: Page/Page column 15 ;
→
反应条件
144-68-3
玉米黄质
+
472-70-8
隐黄质
+
24480-38-4
Alpha-隐黄素
反应条件
triethylsilane; trifluoroacetic acid in dichloromethane T=20°C; 2.5 h; Product distribution / selectivity;
参考文献
Khachik, Frederick
Patent: US2003/220525 A1, 2003 ;
Location in patent: Page/Page column 16-17 ;
1638-05-7
(2E,4E,6E,8E,10E,12E)-2,7,11-三甲基-13-(2,6,6-三甲基-1-环己烯-1-基)-2,4,6,8,10,12-十三六烯醛
+
76686-31-2
→
反应条件
472-70-8
隐黄质
反应条件
(+/-)-2-Ethyloxirane in ethanol 6 h; Inert atmosphereReflux; optical yield given as percent ee;
参考文献
Khachik, Frederick; Chang, An-Ni
Synthesis, 2011 , # 3 art. no. M07010SS, p. 509 - 516
127-40-2
叶黄素
→
反应条件
144-68-3
玉米黄质
+
472-70-8
隐黄质
+
24480-38-4
Alpha-隐黄素
+
60497-64-5
+
60497-65-6
反应条件
triethylsilane; trifluoroacetic acid in dichloromethane T=20°C; 8 h; Product distribution / selectivity;
参考文献
Khachik, Frederick
Patent: US2003/220525 A1, 2003 ;
Location in patent: Page/Page column 15 ;
127-40-2
叶黄素
→
反应条件
反应条件
triethylsilane; trifluoroacetic acid in dichloromethane T=20°C; 5 - 10 h; Product distribution / selectivity;
参考文献
Khachik, Frederick
Patent: US2003/220525 A1, 2003 ;
Location in patent: Page/Page column 7-8 ;
127-41-3
→
反应条件
472-70-8
隐黄质
反应条件
1.1: toluene-4-sulfonic acid; trimethyl orthoformate / hexane / 20 °C / Inert atmosphere 2.1: potassium carbonate; tert.-butylhydroperoxide; sodium hypochlorite / acetonitrile; water / 9.5 h / -5 - 0 °C / Inert atmosphere; Cooling with ice-salt 3.1: sodium tetrahydroborate / ethanol / 4 h / 10 - 20 °C 4.1: hydrogenchloride / water; acetone / 3.16 h / 20 °C / Inert atmosphere 5.1: immobilized lipase PS (pseudomonas cepacia) / ethyl acetate / 20 °C / Inert atmosphere 6.1: potassium hydroxide / dichloromethane; methanol / 2 h / 0 °C / Inert atmosphere 6.2: pH 5 7.1: toluene / 1.5 h / -20 °C / Inert atmosphere 8.1: methanol / 0 - 20 °C 9.1: (+/-)-2-Ethyloxirane / ethanol / Reflux; Inert atmosphere View Scheme
参考文献
University of Maryland, College Park
Patent: US8222458 B2, 2012 ;
14398-37-9
→
反应条件
472-70-8
隐黄质
反应条件
1.1: potassium carbonate; tert.-butylhydroperoxide; sodium hypochlorite / acetonitrile; water / 9.5 h / -5 - 0 °C / Inert atmosphere; Cooling with ice-salt 2.1: sodium tetrahydroborate / ethanol / 4 h / 10 - 20 °C 3.1: hydrogenchloride / water; acetone / 3.16 h / 20 °C / Inert atmosphere 4.1: immobilized lipase PS (pseudomonas cepacia) / ethyl acetate / 20 °C / Inert atmosphere 5.1: potassium hydroxide / dichloromethane; methanol / 2 h / 0 °C / Inert atmosphere 5.2: pH 5 6.1: toluene / 1.5 h / -20 °C / Inert atmosphere 7.1: methanol / 0 - 20 °C 8.1: (+/-)-2-Ethyloxirane / ethanol / Reflux; Inert atmosphere View Scheme
参考文献
University of Maryland, College Park
Patent: US8222458 B2, 2012 ;
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