1-甲基-6,7-二甲氧基-3,4-二氢异喹啉合成路线 （共 34 条）
反应条件
1: 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=0 - 20°C; 1 h;
2: 4-(trifluoromethyl)-benzyl bromide in tetrahydrofuran; hexane
T=0°C; 1 h;
3: With (R,R)-MESsDPEN; formic acid; triethylamine; [Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2 in acetonitrile
48 h; Product distribution / selectivity;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2005/118548 A1, 2005 ;
Location in patent: Page/Page column 23-24 ;
WO 2005/118548 A1
反应条件
1: 75 percent / phenethole / 10percent Pd/C / 1 h / Heating
2: 25 percent / SeO2
3: 50 percent / NH2OH
4: 52 percent / Ac2O / Heating
View Scheme
参考文献
Postaire, E.; Martinez, D.; Viel, C.; Chastagnier, M.; Hamon, M.
Bulletin de la Societe Chimique de France, 1988 , # 6 p. 982 - 988
反应条件
1: 95 percent / sodium ethoxide / methanol / 6 h / Ambient temperature
2: 94 percent / hydrogen / platinum-on-activated-carbon catalyst / methanol
View Scheme
参考文献
Kobor, Jeno; Fueloep, Ferenc; Bernath, Gabor
Heterocycles, 1986 , vol. 24, # 8 p. 2227 - 2231
参考文献
Brossi,A. et al.
Helvetica Chimica Acta, 1960 , vol. 43, p. 1459 - 1472
Full Text Show Details
Brossi et al.
Chimia, 1958 , vol. 12, p. 114
